Asthma & COPD drugs Flashcards
1 st line management of acute asthma exacerbation (3)
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Is it better to give oral or IV prednisolone?
Bioavailability of Prednisolone (oral) is the same (speed wise) to Hydrocortisone IV -> so give IV only if patient’s so short of breath that they cannot speak/swallow/ unconscious
Tx of acute asthma exacerbation
Oxygen - give via nasal cannula/mask to get O2 sats between 94 and 98%
Salbutamol - 2.5 - 5mg nebulised
Hydrocortisone - 100mg IV or prednisolone 40mg oral
Ipratropium - 500mcg nebulised
(give these four IMMEDIATELY, use O2 driven nebs if possible)
Theophylline - IV
Magnesium sulphate - IV
(CONSULT A SENIOR PHYSICIAN)
Escalate care - if intubation and invasive ventilation are required
Steps in chronic asthma management
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MoA of Xhantine
Inhibits phosphodiesterase -> increased cAMP
Side effects of Xhantine
- significant - need to monitor levels
SEs: pain, nausea, cramping, vomiting, diarrhoea, arrhythmias
What’s the role of leukotrienes in athma?
- leukotrienes = inflammatory mediators released by Mast cells
- excess leukotrienes attract eosinophils
MoA and use of Montelukast (how much)
Montelukast 10mg once a day blocks the effect of leukotrienes *especially effective for people
with allergic type of asthma (ones that also suffer from hay fever etc)
Symptoms of long-term steroid use/ Cushing’s
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What is the surgery that is possibly used in chronic management of severe asthma?
Bronchial Thermoplasty -> where bronchoscope is used to burn part of smooth muscle that is contracted in the airways
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What is possible specialist medical Rx in severe asthma?
Monoclonal antibodies
Management of COPD exacerbation
- Salbutamol 5mg (nebuliser)
- Iprapropium 500 mcg (nebuliser)
- Corticosteroids: either Prednisolone 40mg oral or Hydrocortisone 200mg IV
- antibiotics
How can be nebuliser administrated and why in a patient with COPD?
Neb via air if at risk of type II resp failure
MRCP breathlessness scale
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GOLD staging of COPD
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