Asthma Flashcards
1
Q
What is the duration of action of a LABA?
How long does a LABA protect against histamine challenge?
Does tolerance develop to the protective effect of LABA?
Effect on mortality of LABA?
A
Protective against EIA for up to 12h
24h
Yes
Increase in mortality
2
Q
Are ICS associated with reduced adult height?
Do ICS change natural hx of asthma?
A
Yes - 1.3cm shorter than control group
No effect on natural hx of asthma or wheeze and does not prevent lung function decline or reduce airway reactivity
3
Q
Mechanism of action of inhaled corticosteroid?
A
Inhibits phospholipase A2 = prevents production of eicosanoids.
Starting doses:
beclamethasone/budesonide 400mcg/day (max 1000)
Fluticasone 200mcg/day (Max 500)
