Asthma

Question 1

Gene that plays a significant role in regulating airway mucus production.

Answer 1

MUC5AC

Question 2

Benralizumab mechanism of action

Answer 2

• Binds to the alpha-subunit of the IL-5 receptor, inhibiting activation and proliferation of eos, and FcgRIIa on NK cells, resulting in eos and basophil apoptosis by antibody-dependent cell-mediated cytotoxicity

Question 3

Effect of Omalizumab on virus replication

Answer 3

• Omalizumab reduces IgE and the high-affinity IgE receptor on DCs, leading to the restoration of type I interferon production.

Question 4

Biologics with black box warning for anaphylaxis

Answer 4

• Omalizumab
• Reslizumab

Question 5

Zoster vaccine recommendation

Answer 5

• Recommended for adults 50 yrs or older 4 weeks before initiation of mepolizumab unless the patient is at heightened risk of disseminated infection with vaccination (eg, on prednisone >/= 20 mg daily for > 2 weeks)

Question 6

Avoid _________ in patients who are scheduled to receive live attenuated vaccines.

Answer 6

• Tezepelumab

Live attenuated vaccines: measles, mumps, rubella combined vaccine, rotavirus, smallpox, chickenpox, yellow fever, and intranasal influenza

Question 7

IL-13 role in asthma

Answer 7

• Contribute to goblet cell metaplasia that leads to an increase in mucin production

Question 8

Rescue ICS/LABA (formoterol) has been shown to prevent _____________.

Answer 8

exacerbations