Asthma Flashcards
What are some s/s of asthma?
On-and-off nature of symptoms**
- Dyspnea/chest tightness
- Wheezing
- Cough
- Tachypnea/cardia
- Hypoxemia
- Airflow obstruction on PFT
- Bronchial hyperresponsiveness
SABA side effects
Adrenergic stuff
- Tremor
- Shakiness
- Lightheadedness
- Cough
- Palpitations
- Hypokalemia
- Tachycardia
- Hyperglycemia
ICS side effects
- Growth concerns in young children
- Hyperglycemia, fracture risk
- Oropharyngeal candidiasis**
- Dysphonia**
Use lowest dose possible and decrease dose 25-50% after stable for 3 months
ICS pearls
Monotherapy for control only
- Counsel to rinse and spit after use
- Avoid DPIs in children <4
- NEVER shake DPIs, but shake MDIs
- Avoid DPIs in milk allergy
- Budesonide nebulizer preferred in children <4
Which ICS has less thrush/hoarseness?
Ciclesonide
Which ICS has more thrush/hoarseness?
Fluticasone
Which ICS inhalers are MDIs that do not need to be shaken?
Qvar RediHaler (Beclomethasone)
Ciclesonide (Alvesco)
Which ICS is preferred in children <4?
Budesonide nebulized
Probably asthma > COPD when…
- Multiple symptoms
- Symptoms vary over time (worse at night/early morning)
- Identifiable triggers
Probably COPD > asthma when…
- Chronic sputum production
- Isolated cough
- SOB -> dizziness, lightheadedness, tingling
- Chest pain
- Exercise-induced dyspnea with stridor
How to assess asthma control
- Symptom control
- Risk factors
Symptom control questions
Daytime asthma symptoms more than twice per week?
Any night awakening due to asthma?
Reliever (not including ICS/formoterol) used for symptoms (not prior to exercise) more than twice per week?
Any activity limitation due to asthma?
Symptom control scores
Well controlled - 0
Partially controlled - 1-2
Uncontrolled - 3-4
Risk factors for exacerbation
- No ICS
- Poor adherence/technique
- High SABA use
- Comorbidities
- Smoking, allergens, pollution
- Major socioeconomic problems
- Low FEV1
- Sputum/eos
- Previous exacerbation (esp. if intubated)
Additional risk factor for fixed airflow limitation
Preterm/LBW
Risk factors for medication side effects
- Frequent oral CS (especially with CYP450 inhibitors)
- Potent or high-dose ICS
- Long term
- Poor inhaler technique
Step 1-2 Symbicort
Low dose PRN
1 puff whenever needed
Step 3 Symbicort
Low dose maintenance + PRN
1 puff once or twice* daily + 1 puff whenever needed
Step 4 Symbicort
Medium dose maintenance + PRN
2 puffs twice daily + 1 puff whenever needed
Step 5 Symbicort
Medium-high dose maintenance + PRN
2 puffs twice daily + 1 puff whenever needed
How do you step down?
Document baseline status
- Write asthma action plan
- Lower ICS dose by 25-50% every 2-3 months
- DO NOT STOP ICS unless needed to temporarily confirm diagnosis
Factors that increase asthma-related death
- History of asthma requiring intubation and mechanical ventilation
- Hospitalization <1 year
- Recent oral steroid
- Not currently using ICS
- Psycho problems, allergies
- Poor adherence
- Comorbidities
Outpatient self-management of asthma exacerbation
Increase usual reliever
Increase usual controller
Add oral steroid (call Dr)
Mild-moderate exacerbation symptoms
- Talking in phrases
- Prefers sitting to lying
- Not agitated
- HR 100-120
- Osat 90-95%
- PEF >50%
Severe exacerbation symptoms
- Talking in words
- Sitting hunched
- Agitated
- RR >30
- HR >120
- Osat <90%
- PEF <50%
Mild-moderate exacerbation treatment in primary care
SABA 4-10 puffs by MDI + spacer, repeat every 20 minutes for 1 hour
Prednisolone 40-50 mg
Controlled oxygen target 93-95%
After 1 hour, SABA 4-10 puffs q3-4h or 6-10 puffs q1-2h
Mild-moderate exacerbation treatment inpatient
SABA +/- ipratropium
Controlled oxygen
Oral steroids
Severe exacerbation treatment inpatient
SABA +/- ipratropium
Controlled oxygen
Oral steroids (can give IV if needed)
Consider IV magnesium (if persistent hypoxia, FEV1 <25-30%)
Consider high dose ICS (ED only, give on discharge)
When should you consider ICU transfer?
Drowsiness, confusion, silent chest*
Continuing deterioration
When could you consider discharge planning after a 1 hour reevaluation?
FEV1 or PEF 60-80%, symptoms improved
When should you follow up with a patient after discharge?
1 week
COVID considerations
Avoid nebulizers
Exacerbation treatment monitoring
Steroids: glucose, WBC
Bronchodilators: HR, frequency
Wheezing, accessory muscle use, cyanosis
PEF/FEV/HR/Osat 3x daily