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AI 2023 > Asthma > Flashcards

Asthma Flashcards

1
Q

What factors may predict could ask my response to anti-IgE ?

A

Blood eosinophils, equal or greater than 260 per microliter++
FeNo >= 20 ppb +
Allergen driven symptoms +
Childhood Onset, asthma +

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2
Q

Is a patient eligible for anti-IgE for severe allergic asthma?

A

Sensitization on skin prick testing or specific IGE
Total serum IGE and weight within dosage range
Exacerbations in last year

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3
Q

Is the patient eligible for anti-IL5 or anti-IL5R receptor for severe eosinophilic asthma ?

A

Exacerbations in last year
Blood eosinophils >= 300/uL

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4
Q

What factors may predict good asthma response to anti IL5 or IL5R?

A

Higher blood eosinophilia+++
More exacerbations in previous year +++
Adult onset of asthma ++
Nasal polyposis ++

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5
Q

Is the patient eligible for anti IL4R for severe eosinophilic asthma?

A

Exacerbation in last year
Blood eosinophils >= 150 or FeNO >=25
Or
Need for maintenance oral corticosteroids

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6
Q

What factors may predict good asthma response to anti IL4R?

A

Higher blood eosinophils +++
Higher FeNO

Anti IL4R may also be used to treat
Moderate /severe atopic dermatitis
Nasal polyposis

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7
Q

Factors that increase FENO levels

A

IVAN

Increase:

Viral URI
allergic rhinitis
Nitrate rich diet

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8
Q

Factors that decrease FeNO

A

CCSPAS
Caffeine
Cystic fibrosis
Smoking
Pulmonary hypertension
Alcohol consumption
Spirometric maneuvers

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9
Q

Zileuton MOA

A

Blocks 5-Lipoxygenase

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10
Q

Zafirlukast and Montelukast MOA

A

Blocks LTC4, LTD4, LTE4 receptors (cysteinyl leukotriene receptors aka cysLT1 receptors)

Reduce bronchoconstriction, mucus buildup in lungs, lung inflammation

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11
Q

NSAID with no risk of cross reactivity in AERD pts?

A

Celecoxib- a selective COX2 inhibitor

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12
Q

Physiologic changes in asthma in pregnancy

A

Increase in minute ventilation
- normal : compensated resp alkalosis
- related to circulating progesterone levels
Lung volume changes
- increase TV
- decrease RV, FRC

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13
Q

Minor criteria ABPA

A

Aspergillus in Sputum
History of expectorated brown plugs
Delayed Arthus skin test reaction to aspergillus antigen

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14
Q

Alcohol causes theophylline levels to increase or decrease ?

A

Increase

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15
Q

OCPs cause theophylline levels to increase or decrease

A

Increase

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16
Q

Rifampin causes theophylline levels to increase or decrease

A

Decrease

17
Q

Phenobarbital and phenytoin cause theophylline levels to

A

Decrease

18
Q

Zileuton causes theophylline levels to

A

Increase

AI 2023 (2 decks)

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