Aspirin Flashcards
When was the name ‘Aspirin’ selected and registered as a trade name?
23/1/1899
Aspirin was named for ‘a’ from acetyl and ‘spir’ from the spirea plant.
What year was the US patent for Aspirin granted?
1899
What was the first water-soluble form of Aspirin introduced?
1900
Who was the German chemist that experimented with salicin in 1828?
J.A. Buchner
What are the pain-reducing and anti-inflammatory properties extracted from salicin?
Salicylic acid
What is the alternative name for salicylic acid identified by Hermann Kolb?
Ortho-oxybenzoic acid
When were the anti-rheumatic effects of salicylic acid clinically proven?
1876
What are the effects of salicylic acid?
- Analgesic (pain-killing)
- Anti-pyretic (fever-relieving)
When did Aspirin become widely available over the counter?
1915
What happened to the Aspirin trademark after WWI?
It was lost by Germany in the USA, UK, and France.
Who bought back the Bayer Aspirin trademark in the USA in 1994?
Bayer
Who first prescribed willow bark and leaves for pain and fever?
Hippocrates (440-377 B.C.)
What significant event regarding willow bark extract occurred in 1763?
The first scientific study was presented to the Royal Society in London.
Who was Felix Hoffmann and what did he contribute to Aspirin?
A chemist who made the acetyl derivative to help his father’s arthritis.
What did Hoffmann produce by acetylating salicylic acid?
Acetylsalicylic acid
What was significant about the testing conducted by Hoffmann and Dreser?
It included toxicity and activity tests on animals.
What type of trial did Hoffmann subject the new product to?
A year-long clinical trial
Fill in the blank: The pain-relieving effects of Salix and Spiraea species were known in many _______.
cultures
True or False: Salicylic acid was less acidic and had fewer side effects than its sodium salt.
False
