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ASMs > ASMs mechanism > Flashcards

ASMs mechanism Flashcards

1
Q

Phenytoin SE

A

osteopenia, hepatotoxicity, gum hypertrophy, rash

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2
Q

SE CBZ

A

hyponatremia, leukopenia, hepatotoxicity, rash, SJS/TEN

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3
Q

SE Phenobarbital/Primidone (Mysoline®)

A

joint contractures, sedation, depression, DRESS

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4
Q

VPA

A

increased appetite, wt gain, hair loss, hepatotoxicity, thrombocytopenia, polycystic ovary, worsen ADHD

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5
Q

Ethosuximide

A

rash, nausea/decreased appetite, agranulocytosis (rare)

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6
Q

Lacosamide (Vimpat)-

A

PR prolongation

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7
Q

Levetiracetam (Keppra)-

A

Irritability, depression, mood

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8
Q

Clonazepam (Klonopin)/Clorazepate (Tranxene)-

A

Dizziness, sedation, respiratory depression, drooling

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9
Q

Lamotrigine (Lamictal)-

A

diplopia, tremor, insomnia, rash, SJS

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10
Q

Oxcarbazepine (Trileptal)

A

diplopia, rash, hyponatremia

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11
Q

Pregabalin (Lyrica)/Gabapentin (Neurontin)-

A

weight gain, dizziness

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12
Q

Topiramate (Topamax®)/Zonisamide (Zonegran®)

A

urolithiasis, tingling, weight loss, word finding, acidosis, oligohidrosis, glaucoma

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13
Q

Perampanel (Fycompa)-

A

weight gain, irritability (especially in teenagers)

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14
Q

Ezogabine/retigabine (Potiga)-

A

pigmentary retinopathy leading to visual loss in 1/3, blue discoloration, urinary retention

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15
Q

Brivaracetam (Briviact)-

A

irritability, suicidality

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16
Q

Vigabatrin (Sabril®)

A

peripheral visual loss, MRI white matter changes

17
Q

Rufinamide (Banzel®)-

A

QT interval shortening, nausea, decreased appetite

18
Q

Felbamate (Felbatol®)-

A

bone marrow suppression and liver toxicity

black box warning aplastic anemia, sometimes fatal. Discontinue if any evidence of bone marrow depression occurs.

19
Q

Cytochrome P450 system inducers

A

Carbamazepine
phenytoin
phenobarbital, primidone
felbamate

20
Q

Cytochrome P450 system inhibitors

A

VPA

Felbamate

21
Q

Cytochrome P450 system inducers

A

Carbamazepine
phenytoin
phenobarbital, primidone
felbamate

22
Q

Influenced by p450 inducers/inhibitors

A 
Ethosuximide
oxcarbazepine 
Lamotrigine*
zonisamide (Zonegran®), topiramate 
Rufinamide

ETOZ LR

23
Q

Uridine glucuronyl transferase (UGT) MEChanism

A

Lamotrigine (Lamictal®), oxcarbazepine (Trileptal®), valproate (Depakote®)

24
Q

Epoxide hydrolase

metabolism

A

Carbamazepine

25
Q

Protein bindings

A

VPA/Phenytoin

ASMs (1 decks)

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