ASA OD Flashcards
1
Q
Tox levels
A
300 mg/kg = severe/lethal
2
Q
What pH state is ASA tox worse in?
A
acid
3
Q
How does ASA cause metabolic acidosis?
A
via uncoupling of oxidative phosphorylation
via uncoupling of Krebs cycle
4
Q
How does ASA cause respiratory alkalosis?
A
Direct effects on brain raise RR
Skeletal mm metabolism inc CO2
Pt tires out, RR decreases, causes resp acidosis
5
Q
Non-cardiogenic pulmonary edema
A
ASA increases pulmonary vascular permeability
Not a funx of cardiac system, remains unaffected
6
Q
Antiplatelet activity
A
acute OD = bleeding rare
chronic OD = possible
7
Q
ASA ototoxicity
A
hearing loss correlated with ASA levels
reversible
8
Q
Acute adult ASA OD findings
A
N/V Tinitus Sweating Hyperventilation Respiratory alkalosis Metabolic acidosis
9
Q
Chronic adult ASA OD findings
A
Normal ASA serum level Neuro symptoms -tremor -agitation -bizarre behavior -memory deficits -stupor -seizure -tinnitus
10
Q
ASA OD treatment
A
charcoal acid base correction hydration no specific antidote WBI (go-lytely) urine alkalinization (bicarb)
