Articles Flashcards
What is the effect of Itaconate?
Itaconate is a crucial anti-inflammatory metabolite that acts via Nrf2 to limit inflammation and molulate type 1 interferons.
What is the effect of sTREM2?
sTREM2 enhances microglial proliferation, migration, clustering in the vicinity of amyloid plaques and the uptake and degradation of Aβ. So sTREM2 has a protective role against amyloid pathology and related toxicity, and increasing sTREM2 can be explored for AD therapy.
Wat is the effect of JAK1?
JAK1 mediates signalling from multiple cytokine receptors and has a critical function in protection against mycobacterial infections and possibly the immunological surveillance of cancer.
What is the effect of CD1a on Langerhans cells?
CD1a amplifies inflammatory responses that were mediatede by Th17 cells that reacted to self lipid antigens. Treatment with blocking antibodies to CD1a alleviated skin inflammation, so CD1a is a potential therapeutic target in inflammatoy skin disease.
Why is IgA better than IgG?
Crosslinking of the IgA Fc receptor (FcαRI) by complexed IgA triggers recruitmentof neutrophils, suggesting an additional pro-inflammatory role. IgA stimulation induces a more pronounced release of pro-inflammatory cytokines and chemokines than IgG.
What did Article 6 found out about SARS-Cov-2?
They detected SARS-CoV-2 reactive CD4+ T-cells in ~40%-60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS-CoV-2.
What effect does the Candida albicans morphology have on Th cells?
C. albicanas morphology drives distinct T helper cell responses that provide tissue-specific protection. These findings provide insight into compatmentalization of Th2 responses and have critical implications for vaccine strategies.
What is the effect of IL-22 in lymph nodes?
IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs. IL-22 blocking agents could be used in B-cell-mediated autoimmune conditions.
