Article 2: Major Groups of Disease-Causing Bacteria (Article) Flashcards
Aerobic Gram-Positive Rods (3 important genera)
Bacillus, Corynebacterium, and Listeria
Two medically important genera that produce spores
Bacillus and Clostridium
Bacillus anthracis (Morphology, Spore Production, Motility, Unique Properties)
Large: end-to-end chains, Yes, No, Poly-D-glutamic acid capsule; spores
Bacillus cereus (Morphology, Spore Production, Motility, Unique Properties)
Large, Yes, Yes; 50% of strains, Spores
Corynebacterium diphtheriae (Morphology, Spore Production, Motility, Unique Properties)
Small and narrow, No, No, Pleomorphic; Chinese Characters (divides via snapping fission)
Listeria monocytogenes (Morphology, Spore Production, Motility, Unique Properties)
Small, No, Yes; tumbling motion, Grows at 3-4 degrees C; grows intracellulaly
Anaerobic Spore-Forming Gram-Positive Rods
Clostridium (only genus)
- Produce endospores to survive adverse conditions
e. g. C. botulinum, C. tetani, C. perfringens, C. difficile
Clostridium botulinum
- Fastidious spore-forming gram-positive rod shaped organism
- Production of a NEUROTOXIN results in disease (i.e. flaccid paralysis)
- Commonly isolated in SOIL and WATER
Clostridium tetani
- Tennis rackt/drumstick appearance due to terminal ENDOSPORE
- Difficult to grow in vitro due to extreme OXYGEN SENSITIVITY
- Production of a NEUROTOXIN (tetanospasmin) causes spastic paralysis (i.e. lockjaw, arching of back, and respiratory muscle spasms)
- Commonly found in SOIL
Clostridium perfringens
- Hemolytic and produces several toxins (alpha, beta, epsilon, and iota)
- Grows rapidly in tissue and in culture
- NOT motile (unlike other Clostridia)
- Cellulitis, suppurative myositis, gas gangrene, food poisoning
Clostridium difficile
- Associated with prior antibiotic use and other chemotherapies
- Extremely sensitive to oxygen
- WATERY DIARRHEA
Gram-Positive Cocci
Staphylococcus, Streptococcus, and Enterococcus
Staphylocci
Catalase POSITIVE and grow in large clusters
- Grow in media with up to 10% salt
- Aerobic or anaerobic
- Found on skin and mucous membranes
Streptococci
Catalase NEGATIVE and grow in chains
Enterococcus
Catalase NEGATIVE and is in the Lancefield D group