arterial insufficiency Flashcards
most common type of ulcers
venous
% of LE ulcerations due to arterial insufficiency
5-10%
% of blockage that vasodilation can compete with
50%
three types of arteries
elastic
muscular
arterioles
elastic arteries
aorta and branches
maintain BP
muscular arteries (distributing)
femoral and brachial
average lumen diameter= 4mm
arterioles
sympathetic vasoconstriction
average lumen diameter of 37 micrometer
capillaries
single layer of endothelial cells on thin basement membrane
1 mm log, 9 micrometer wide
oxygen and nutrients in blood diffuse along capillary concentration gradients into the tissue
thixotropic fluid definition
changes viscosity, thicker with less water, problems in small capillaries because blood is this way
with less movement blood becomes more or less viscous
more
primary determinant of blood viscosity
hematocrit
blood sludging results from
dehydration and polycythemia
(internet says severe burns and crush injuries)
blood sludging
RBCs clump together in blood vessels
aka intravascular agglutination
muscles are more efficient in aerobic or anaerobic conditions
aerobic, suggesting muscles can be trained to decrease symptoms of claudication over time
causes of arterial insufficiency
trauma
acute embolism
diabetes mellitus
rheumatoid arthritis
thromboangiitis (buerger’s disease)
arteriosclerosis
thromboangiitis (Buerger’s disease)
closing of small vessels
they become inflamed and swollen then narrow or get blocked by blood clots
arteriosclerosis
thickening/hardening of arterial walls
atherosclerosis
systemic, degenerative process, arterial lumen is gradually and progressively encroached upon
high LDLs
enhance cholesterol deposition
HCLs
serve a protective function
% of stenosis to have claudication
50%
intermittent claudication possible arteries blocked
iliofemoral and infrapopliteal
flow chart leading to arterial ulcers
arterial insufficiency -> intermittent claudication -> ischemic rest pain -> ulcer
ulceration and gangrene from AI result when
O2 requirements of local tissue exceed perfusion
few facts about rutherford classification system for chronic limb ischemia
arterial insufficiency
higher number is worse
risk factors contributing to arterial ulceration
hyperlipidemia and elevated LDL
smoking
diabetes
hypertension
trauma
advanced age
smoking as a risk factor for arterial ulcers
only modifiable risk factor
nicotine causes vasoconstriction
decreases available O2
diabetes as a risk factor for arterial ulcers
vessel walls calcify
decrease collagen synthesis, angiogenesis and fibroblast proliferation
reduces tensile strength of wounds
impairs body ability to fight infections
hypertension as a risk factor for arterial ulcers
intimal layer of arteries fragile and easily traumatized
systolic is more damaging than diastolic