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ART Flashcards

1
Q

ABC

A

Abacavir (Ziagen)

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2
Q

Abacavir class

A

NRTI

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3
Q

FTC

A

Emtricitabine (Emtriva)

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4
Q

Emtricitabine class

A

NRTI

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5
Q

3TC

A

Lamivudine (Epivir)

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6
Q

Lamivudine class

A

NRTI

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7
Q

TDF

A

Tenofovir disoproxil fumarate (Viread)

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8
Q

Tenofovir class

A

NRTI

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9
Q

AZT

A

Zidovudine (Retrovir)

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10
Q

ZDV

A

Zidovudine (Retrovir)

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11
Q

Zidovudine class

A

NRTI

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12
Q

DOR

A

Doravirine (Pifeltro)

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13
Q

Doravirine class

A

NNRTI

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14
Q

EFV

A

Efavirinez (Sustiva)

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15
Q

Efavirenz class

A

NNRTI

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16
Q

ETR

A

Etravirine (Intelence)

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17
Q

Etravirine class

A

NNRTI

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18
Q

NVP

A

Nevirapine (Viramune)

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19
Q

Nevirapine class

A

NNRTI

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20
Q

RPV

A

Rilpivirine (Edurant)

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21
Q

Rilpivirine class

A

NNRTI

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22
Q

ATV

A

Atazanavir (Reyataz)

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23
Q

Atazanavir class

A

Protease inhibitor

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24
Q

DRV

A

Darunavir (Prezista)

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25
Q

Darunavir class

A

Protease inhibitor

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26
Q

FPV

A

Fosamprenavir (Lexiva)

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27
Q

FOS-APV

A

Fosamprenavir

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28
Q

Fosamprenavir class

A

Protease inhibitor

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29
Q

RTV

A

Ritonavir (Norvir)

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30
Q

Ritonavir class

A

Protease inhibitor/Booster

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31
Q

SQV

A

Saquinavir (Invirase)

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32
Q

Saquinavir class

A

Protease inhibitor

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33
Q

TPV

A

Tipranavir (Aptivus)

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34
Q

Tipranavir class

A

Protease inhibitor

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35
Q

T-20

A

Enfuviritide (Fuzeon)

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36
Q

Enfuviritide class

A

Fusion inhibitor

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37
Q

MVC

A

Maraviroc (Selzentry)

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38
Q

Maraviroc class

A

CCR5 antagonist

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39
Q

DTG

A

Dolutegravir sodium (Tivicay)

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40
Q

Dolutegravir class

A

Integrase inhibitor

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41
Q

RAL

A

Raltegravir (Isentress)

42
Q

Raltegravir class

A

Integrase inhibitor

43
Q

BIC

A

Bictegravir

44
Q

Bictegravir class

A

Integrase inhibitor

45
Q

FTR

A

Fostemsavir

46
Q

Fostemsavir class

A

Attachment inhibitor - binds gp120 on HIV surface preventing CD4 entry

47
Q

IBA

A

Ibalizumab-uiyk (Trogarzo)

48
Q

Ibalizumab-uiyk class

A

Post-attachment inhibitor - blocks CD4 receptors on surface of immune cells needed by HIV to enter cell

49
Q

COBI/c

A

Cobicistat (Tybost)

50
Q

Cobicistat class

A

Pharmacokinetic enhancer

51
Q

Epzicom

A

ABC / 3TC

Abacavir / Lamivudine

52
Q

Triumeq

A

ABC / DTG / 3TC

Abacavir / Dolutegravir / Lamivudine

53
Q

Trizivir

A

ABC / 3TC / ZDV

Abacavir / Lamivudine / Zidovudine

54
Q

Evotaz

A

ATV / COBI

Atazanavir / cobicistat

55
Q

Biktarvy

A

BIC / FTC / TAF

Biktegravir / emtricitabine / Tenofovir alafenamide fumarate

56
Q

Prezcobix

A

DRV / COBI

Darunavir / cobicistat

57
Q

Symtuza

A

DRV / COBI / FTC / TAF

Darunavir / cobicistat / Emtricitabine / Tenofovir alafenamide fumarate

58
Q

Dovato

A

DTG / 3TC

Dolutegravir / Lamivudine

59
Q

Juluca

A

DTG / RPV

Dolutegravir/ Rilpivirine

60
Q

Delstrigo

A

DOR / 3TC / TDF

Doravirine / Lamivudine / Tenofovir disoproxil fumarate

61
Q

Atripla

A

EFV / FTC / TDF

Efavirenz / Emtricitabine / Tenofovir disoproxil fumarate

62
Q

Symfi

A

EFV / 3TC / TDF

Efavirenz / Lamivudine / Tenofovir disoproxil fumarate

63
Q

Genvoya

A

EVG / COBI / FTC / TAF

Elvitegravir / Cobicistat / Emtricitabine / Tenofovir alafenamide fumarate

64
Q

Stribild

A

EVG / COBI / FTC / TDF

Elvitegravir / Cobicistat / Emtricitabine / Tenofovir disoproxil fumarate

65
Q

Odefsey

A

FTC / RPV / TAF

Emtricitabine / Rilpivirine / Tenofovir alafenamide fumarate

66
Q

Complera

A

FTC / RPV / TDF

Emtricitabine / Rilpivirine / Tenofovir disoproxil fumarate

67
Q

Descovy

A

FTC / TAF

Emtricitabine / Tenofovir alafenamide fumarate

68
Q

Truvada

A

FTC / TDF

Emtricitabine / Tenofovir disoproxil fumarate

69
Q

Combivir

A

3TC / ZCV

Lamivudine / Zidovudine

70
Q

Kaletra

A

LPV / RTV

Lopinavir / Ritonavir

71
Q

Atripla dosing

A

One tablet daily (complete regimen)

Take on empty stomach at bedtime (causes drowsiness)

72
Q

Biktarvy dosing

A

One tablet daily (complete regimen)

Can be taken with or without food

73
Q

Complera dosing

A

One tablet daily (complete regimen)

Take with food

74
Q

Delstrigo dosing

A

One tablet daily (complete regimen)

Take with or without food

75
Q

Dovato dosing

A

One tablet daily (complete regimen)

Take with or without food

76
Q

Genvoya dosing

A

One tablet daily (complete regimen)

Take with food

77
Q

Juluca dosing

A

One tablet daily (complete regimen)

Must be taken with a meal

78
Q

Odefsey dosing

A

One tablet daily (complete regimen)

Must be taken with a meal

79
Q

Stribild dosing

A

One tablet daily (complete regimen)

Take with food

80
Q

Symfi dosing

A

One tablet daily (complete regimen)

Take on empty stomach, at bedtime

81
Q

Symtuza dosing

A

One tablet daily (complete regimen, can be combined if resistance)
Should be taken with food

82
Q

Triumeq dosing

A

One tablet daily (complete regimen)

Take with or without food

83
Q

Bone density effects

A

Greater loss in TDF compared to other NRTIs, especially with PK booster
Osteomalacia can be associated with renal tubulopathy and urine phosphate wasting

Decrease in BMD can be seen with initiation of any ART regimen

84
Q

Bone marrow suppression

A

Zidovudine - Anemia and neutropenia

85
Q

QTc prolongation

A

Rilpivirine

Efavirenz

86
Q

PR prolongation

A

Atazanavir / ritonavir

Lopinavir / ritonavir

87
Q

Cardiovascular disease

A

Abacavir - Risk of MI

Boosted Darunavir - Cardiovascular events in some cohorts

Lopinavir / ritonavir - Cardiovascular events in some cohorts

88
Q

Cholelithiasis

A

Atazanavir (median 42 months after ATV initiation)

89
Q

DM and insulin resistance

A

Zidovudine

Lopinavir / ritonavir (but NOT boosted atazanavir or darunavir)

90
Q

Increased triglycerides and LDL (NRTI)

A

Zidovudine > Abacavir

91
Q

Increased triglycerides, LDL and HDL

A

TAF (TDF with lower lipid levels than ABC, ZDC, or TAF)

Efavirenz

All ritonavbir or COBI boosted PIs
(LPV/r > DRV/r and ATV/r)

Elvitegravir/c

92
Q

Five recommended initial regimens

A
  1. BIC/TAF/FTC (Biktarvy)
  2. DTG/ABC/3TC (Triumeq)
  3. DTG + (FTC or 3TC) + (TAF or TDF)
    - -Could be TAF/FTC (Descovy) or TDF/FTC (Truvada) or DTG/3TC (Dovato) + (TAF or TDF)
  4. DTG/3TC (Dovato) - EXCEPT HIV RNA > 500K, HBV co-infection, or starting before resistance genotype)
  5. RAL + (FTC or 3TC) + (TAF or TDF)
93
Q

Recommended initial regimen for most people

A

INSTI + 2 NRTIs (or INSTI +1 NRTI)

94
Q

Second line regimens

A
  1. Boosted PI + 2 NRTIs: (DRV/c or DRV/r > ATV/c or ATV/r) + (TAF or TDF) + (FTC or 3TC)
    - -DRV/c/FTC/TAF = Symtuza
  2. NNRTI + 2 NRTIs: (DOR or EFV or RPV) + (TDF or TAF) + (3TC/FTC)
    - -DOR/TDF/3TC = Deltsrigo
95
Q

Regimen when ABC, TAF, TDF cannot be used

A

DTG/3TC - if HIV VL <500K, resistance pattern available and no HBV co-infection

DRV/r + RAL BID - if HIV RNA <100K and CD4 >200

DRV/r + 3TC

96
Q

Cannot use what two regimens if CD4 <200

A

RPV-based regimens

DRV/r + RAL

(Higher rate of virologic failure)

97
Q

Cannot use what three regimens if HIV RNA > 100K

A

RPV-based regimens

ABC/3TC + (EFV or ATV/r)

DRV/r + RAL

(higher rates of failure)

98
Q

Cannot use what 4 regimens if HIV RNA >500K

A

RPV-based

ABC/3TC + (EFV or ATV/r)

DRV/r + RAL

DTG/3TC (little data available)

99
Q

Cannot use what drug with HLA-B*5701

A

ABC - hypersensitivity, potentially fatal

100
Q

What 3 regimens to avoid if starting ARV before resistance testing

A

NNRTI-based

DTG/3TC

ABC including regimens

101
Q

Three recommended regimens to start before resistance testing

A

BIC/TAF/FTC

DTG + (TAF or TDF) + (3TC or FTC)

(DRV/r or DRV/c) + (TAF or TDF) + (3TC or FTC)

102
Q

One pill, once daily regimens (11)

A
  1. BIC/TAF/FTC (Biktarvy)
  2. DOR/TDF/3TC (Delstrigo)
  3. DRV/c/TAF/FTC (Symtuza)
  4. DTG/ABC/3TC (

HIV (4 decks)

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