ART Flashcards
1
Q
ABC
A
Abacavir (Ziagen)
2
Q
Abacavir class
A
NRTI
3
Q
FTC
A
Emtricitabine (Emtriva)
4
Q
Emtricitabine class
A
NRTI
5
Q
3TC
A
Lamivudine (Epivir)
6
Q
Lamivudine class
A
NRTI
7
Q
TDF
A
Tenofovir disoproxil fumarate (Viread)
8
Q
Tenofovir class
A
NRTI
9
Q
AZT
A
Zidovudine (Retrovir)
10
Q
ZDV
A
Zidovudine (Retrovir)
11
Q
Zidovudine class
A
NRTI
12
Q
DOR
A
Doravirine (Pifeltro)
13
Q
Doravirine class
A
NNRTI
14
Q
EFV
A
Efavirinez (Sustiva)
15
Q
Efavirenz class
A
NNRTI
16
Q
ETR
A
Etravirine (Intelence)
17
Q
Etravirine class
A
NNRTI
18
Q
NVP
A
Nevirapine (Viramune)
19
Q
Nevirapine class
A
NNRTI
20
Q
RPV
A
Rilpivirine (Edurant)
21
Q
Rilpivirine class
A
NNRTI
22
Q
ATV
A
Atazanavir (Reyataz)
23
Q
Atazanavir class
A
Protease inhibitor
24
Q
DRV
A
Darunavir (Prezista)
25
Darunavir class
Protease inhibitor
26
FPV
Fosamprenavir (Lexiva)
27
FOS-APV
Fosamprenavir
28
Fosamprenavir class
Protease inhibitor
29
RTV
Ritonavir (Norvir)
30
Ritonavir class
Protease inhibitor/Booster
31
SQV
Saquinavir (Invirase)
32
Saquinavir class
Protease inhibitor
33
TPV
Tipranavir (Aptivus)
34
Tipranavir class
Protease inhibitor
35
T-20
Enfuviritide (Fuzeon)
36
Enfuviritide class
Fusion inhibitor
37
MVC
Maraviroc (Selzentry)
38
Maraviroc class
CCR5 antagonist
39
DTG
Dolutegravir sodium (Tivicay)
40
Dolutegravir class
Integrase inhibitor
41
RAL
Raltegravir (Isentress)
42
Raltegravir class
Integrase inhibitor
43
BIC
Bictegravir
44
Bictegravir class
Integrase inhibitor
45
FTR
Fostemsavir
46
Fostemsavir class
Attachment inhibitor - binds gp120 on HIV surface preventing CD4 entry
47
IBA
Ibalizumab-uiyk (Trogarzo)
48
Ibalizumab-uiyk class
Post-attachment inhibitor - blocks CD4 receptors on surface of immune cells needed by HIV to enter cell
49
COBI/c
Cobicistat (Tybost)
50
Cobicistat class
Pharmacokinetic enhancer
51
Epzicom
ABC / 3TC
| Abacavir / Lamivudine
52
Triumeq
ABC / DTG / 3TC
| Abacavir / Dolutegravir / Lamivudine
53
Trizivir
ABC / 3TC / ZDV
| Abacavir / Lamivudine / Zidovudine
54
Evotaz
ATV / COBI
| Atazanavir / cobicistat
55
Biktarvy
BIC / FTC / TAF
| Biktegravir / emtricitabine / Tenofovir alafenamide fumarate
56
Prezcobix
DRV / COBI
| Darunavir / cobicistat
57
Symtuza
DRV / COBI / FTC / TAF
| Darunavir / cobicistat / Emtricitabine / Tenofovir alafenamide fumarate
58
Dovato
DTG / 3TC
| Dolutegravir / Lamivudine
59
Juluca
DTG / RPV
| Dolutegravir/ Rilpivirine
60
Delstrigo
DOR / 3TC / TDF
| Doravirine / Lamivudine / Tenofovir disoproxil fumarate
61
Atripla
EFV / FTC / TDF
| Efavirenz / Emtricitabine / Tenofovir disoproxil fumarate
62
Symfi
EFV / 3TC / TDF
| Efavirenz / Lamivudine / Tenofovir disoproxil fumarate
63
Genvoya
EVG / COBI / FTC / TAF
| Elvitegravir / Cobicistat / Emtricitabine / Tenofovir alafenamide fumarate
64
Stribild
EVG / COBI / FTC / TDF
| Elvitegravir / Cobicistat / Emtricitabine / Tenofovir disoproxil fumarate
65
Odefsey
FTC / RPV / TAF
| Emtricitabine / Rilpivirine / Tenofovir alafenamide fumarate
66
Complera
FTC / RPV / TDF
| Emtricitabine / Rilpivirine / Tenofovir disoproxil fumarate
67
Descovy
FTC / TAF
| Emtricitabine / Tenofovir alafenamide fumarate
68
Truvada
FTC / TDF
| Emtricitabine / Tenofovir disoproxil fumarate
69
Combivir
3TC / ZCV
| Lamivudine / Zidovudine
70
Kaletra
LPV / RTV
| Lopinavir / Ritonavir
71
Atripla dosing
One tablet daily (complete regimen)
| Take on empty stomach at bedtime (causes drowsiness)
72
Biktarvy dosing
One tablet daily (complete regimen)
| Can be taken with or without food
73
Complera dosing
One tablet daily (complete regimen)
| Take with food
74
Delstrigo dosing
One tablet daily (complete regimen)
| Take with or without food
75
Dovato dosing
One tablet daily (complete regimen)
| Take with or without food
76
Genvoya dosing
One tablet daily (complete regimen)
| Take with food
77
Juluca dosing
One tablet daily (complete regimen)
| Must be taken with a meal
78
Odefsey dosing
One tablet daily (complete regimen)
| Must be taken with a meal
79
Stribild dosing
One tablet daily (complete regimen)
| Take with food
80
Symfi dosing
One tablet daily (complete regimen)
| Take on empty stomach, at bedtime
81
Symtuza dosing
One tablet daily (complete regimen, can be combined if resistance)
Should be taken with food
82
Triumeq dosing
One tablet daily (complete regimen)
| Take with or without food
83
Bone density effects
Greater loss in TDF compared to other NRTIs, especially with PK booster
Osteomalacia can be associated with renal tubulopathy and urine phosphate wasting
Decrease in BMD can be seen with initiation of any ART regimen
84
Bone marrow suppression
Zidovudine - Anemia and neutropenia
85
QTc prolongation
Rilpivirine
Efavirenz
86
PR prolongation
Atazanavir / ritonavir
Lopinavir / ritonavir
87
Cardiovascular disease
Abacavir - Risk of MI
Boosted Darunavir - Cardiovascular events in some cohorts
Lopinavir / ritonavir - Cardiovascular events in some cohorts
88
Cholelithiasis
Atazanavir (median 42 months after ATV initiation)
89
DM and insulin resistance
Zidovudine
Lopinavir / ritonavir (but NOT boosted atazanavir or darunavir)
90
Increased triglycerides and LDL (NRTI)
Zidovudine > Abacavir
91
Increased triglycerides, LDL and HDL
TAF (TDF with lower lipid levels than ABC, ZDC, or TAF)
Efavirenz
All ritonavbir or COBI boosted PIs
(LPV/r > DRV/r and ATV/r)
Elvitegravir/c
92
Five recommended initial regimens
1. BIC/TAF/FTC (Biktarvy)
2. DTG/ABC/3TC (Triumeq)
3. DTG + (FTC or 3TC) + (TAF or TDF)
- -Could be TAF/FTC (Descovy) or TDF/FTC (Truvada) or DTG/3TC (Dovato) + (TAF or TDF)
4. DTG/3TC (Dovato) - EXCEPT HIV RNA > 500K, HBV co-infection, or starting before resistance genotype)
5. RAL + (FTC or 3TC) + (TAF or TDF)
93
Recommended initial regimen for most people
INSTI + 2 NRTIs (or INSTI +1 NRTI)
94
Second line regimens
1. Boosted PI + 2 NRTIs: (DRV/c or DRV/r > ATV/c or ATV/r) + (TAF or TDF) + (FTC or 3TC)
- -DRV/c/FTC/TAF = Symtuza
2. NNRTI + 2 NRTIs: (DOR or EFV or RPV) + (TDF or TAF) + (3TC/FTC)
- -DOR/TDF/3TC = Deltsrigo
95
Regimen when ABC, TAF, TDF cannot be used
DTG/3TC - if HIV VL <500K, resistance pattern available and no HBV co-infection
DRV/r + RAL BID - if HIV RNA <100K and CD4 >200
DRV/r + 3TC
96
Cannot use what two regimens if CD4 <200
RPV-based regimens
DRV/r + RAL
(Higher rate of virologic failure)
97
Cannot use what three regimens if HIV RNA > 100K
RPV-based regimens
ABC/3TC + (EFV or ATV/r)
DRV/r + RAL
(higher rates of failure)
98
Cannot use what 4 regimens if HIV RNA >500K
RPV-based
ABC/3TC + (EFV or ATV/r)
DRV/r + RAL
DTG/3TC (little data available)
99
Cannot use what drug with HLA-B*5701
ABC - hypersensitivity, potentially fatal
100
What 3 regimens to avoid if starting ARV before resistance testing
NNRTI-based
DTG/3TC
ABC including regimens
101
Three recommended regimens to start before resistance testing
BIC/TAF/FTC
DTG + (TAF or TDF) + (3TC or FTC)
(DRV/r or DRV/c) + (TAF or TDF) + (3TC or FTC)
102
One pill, once daily regimens (11)
1. BIC/TAF/FTC (Biktarvy)
2. DOR/TDF/3TC (Delstrigo)
3. DRV/c/TAF/FTC (Symtuza)
4. DTG/ABC/3TC (
