AR Flashcards

1
Q

Inicio

A

Poliartitritis 80%
Oligoartritis 20%

50% insidiosa
50%subita

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2
Q

Inició insidioso

A
>6 semanas 
Fatiga 
Artrslgias 
Febricula
Perdida de peso

10% ascendente
20% monociclico (best pronostico)
70% policlico

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3
Q

Faactores pronosticó

A
FR (+)
Anti- PCC
VSG elevada y PCR (+)
Rx erosiones tempranas ( antes de 2 años)
Edad temprana 
Nódulos reumatoides 
Mayor número de articulaciones
Nivel socio cultura bajo
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4
Q

Consecuencia de artritis crónica

A

Pequeñas- deformidad

Grandes- artrosis

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5
Q

Afectación extraarticular

A
25% nódulos reumatoides- codos 
5- 15%
 S. sjorgen 
 Pulmonares: pleuritis, fibrosis 
 Neuro: neuropagias
Corazón: pericarditis 
Cutánea: vasculitis 

Anemia NORMO- NORMo 10-12 g

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6
Q

HLA

A

HLA DR1
HLA DR4
70% cromosoma 6

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7
Q

Autoanticuerpos

A
Factor reumatoide( 70-80%) Fc Ig inmunogenica 
Anti- PCC (70-80%) ESPECÍFICO 
Anticuerpos antinucleares (50%)
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8
Q

Medir inflamación

A

VSG y PCR
Hemoglobina baja
Trombocitosis

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9
Q

Prueba rx

A

1) Edema de tejidos blandos
2) disminución del espacio articular
3) erosiones marginales * importante
4) subluxacion articular

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10
Q

Cuanto se tarda en destruir hueso

A

2 años

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11
Q

Tratamiento

A

AINES (6 semanas)
Esteoides prednisona menos 15 mg

FARME (6 meses mínimo)
Metrotexate (hígado)
Cloroquina- hidrox (ceguera)
Sulfazalasina

BIOLÓGICOS
Tnf a - infliximab adalimub 
Il-6.     Tocilizumab 
Cd20-  rituximab (bloquean células B) 
Il1- anankira
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