Aptamera Flashcards
1
Q
What is an aptamer
A
Folded single stranded nucleotide
That
Binds to a molecular target
(Small organics, proteins, peptides, cells and tissues)
2
Q
True/False
They are not non-immunogenic
A
False
They are non immunogenic
3
Q
Are they scalable?
A
Yes. They are produced chemically.
4
Q
Their denaturation is not irreversible. True/False?
A
True
It is reversible
5
Q
They are small sized. What is the benefit here?
A
It aids delivery to the biological target
6
Q
What is the disadvantage of it being small sized?
A
Susceptibility to renal clearance
7
Q
Brand name of an aptamer that is approved
A
Pegaptanib
For age related macular degeneration
Target: vascular endothelial growth factor
