April 4 Flashcards
1
Q
What does RyR channel do?
A
It is in Smooth ER, when have increasing Ca in cytosol during action potential, it activates and releases more Ca into cytosol, get skeletal muscle contraction
2
Q
What effect do we see of imperatoxin on the RyR channel?
A
We see that channel stays in a subconductor state, some Ca leaks through
3
Q
What features of the imperatoxin allow it to bind to RyR receptor?
A
It is positively charged on one side, see that some amino acids need to be positive for toxin to work. The receptor has neg AA-s that form salt bridges with + toxin
4
Q
If Imperatoxin is phosphorylated on Thr, does it completely block RyR channel?
A
Yes it does
5
Q
A
