Approach to Weight Gain

Question 1

Systems (HPA/Endocrine)

Answer 1

• Hypothalamus
• Pituitary: Acromegaly
• Thyroid: Hypothyroidism
• Adrenals: Cushing Syndrome
• Pancreas: Insulinoma
• Ovaries/Female: PCOS

Question 2

Cushing Syndrome Causes

Answer 2

Iatrogenic
Hypothalamus (CRH)
Pituitary adenoma
Adrenal adenoma
Ectopic ACTH secretion

Question 3

Iatrogenic

Answer 3

DM: Insulin, sulphonylureas
Anti-psychotic (atypicals): Olanzapine etc.
Anti-epileptics: Sodium Valproate, CBMZ
Streoids/TCM
Others: OCP, TCA

Question 4

Etiologies in women

Answer 4

Pregnancy
PCOS
Pelvic or abdominal masses

Question 5

Fluid Overload/Salt & Water Retention

Answer 5

HF, RF, Liver failure, Protein-losing enteropathy