Approach to Hepatosplenomegaly

Question 1

In splenomegaly, which conditions would result in an FBC with immature/abnormal WBCs

Answer 1

Lympho/myeloproliferative disorders

Question 2

In splenomegaly, which conditions would result in an FBC with cytopenias

Answer 2

Liver disease
AIHA
ITP
Felty syndrome
Congenital anemias

Question 3

In splenomegaly, which conditions would result in an FBC with teardrop cells

Answer 3

Myelofibrosis
Thalassemia

Question 4

In splenomegaly, which conditions would result in an FBC with spherocytes

Answer 4

AIHA
Hereditary spherocytosis

Question 5

Which values of the “R ratio” indicate which disease?

Answer 5

> 5 hepatocellular
<2 cholestatic
2-5 mixed