Approach to dementias Flashcards
1
Q
Whats the three major issues that a clinician should keep in mind when dealing with a patient with dementia?
A
- Whats is the most accurate diagnosis
- Is there a treatable or reversible component?
- Can the physician alleviate the burden on the care giver?
2
Q
What are the clinical differentitaion of major dementias?
A
3
Q
How do you define Mild cognitive impairment?
A
A measurable cognitive problem but DOES NOT impact daily activities
1.5 standard deviations below standarised memory tests
4
Q
What factors predict progression from MCI to AD
A
- Prominent memory defect
- Family history of AD
- Presence of Apo e4 allele
- Small hippocampal volumes
- AD like signature cortical atrophy
- Low CSF AB or elevated tau
5
Q
What proportion of patients with MCI progress to AD in a year
A
12% or 50% in 4 year
6
Q
What is the typical duration of AD
A
8-12 years
