Applied Neuropharmacology

Question 1

What kinds of drugs can be used to treat Parkinsons?

Answer 1

L-DOPA
Carbodopa (decarbocylase antagonist)
Dopamine agonist

Question 2

Side effects of Dopaminergic drugs (carbodopa)

Answer 2

Nausea
Vomiting
Psychosis

Question 3

Side effects of Dopamine antagonists

Answer 3

Worsen Parkinsons and the rigidity associated

Question 4

Positive effects of dopamine antagonists

Answer 4

Improve nausea, vomiting, and psychosis

Question 5

DA antagonists shuouldn’t be used in what condition associated with the nervous system?

Answer 5

Parkinson’s disease

Question 6

What feature of Domperidone makes it ideal for Parkinson’s?

Answer 6

It doesn’t cross the BBB so can be used to combat the side effects of other drugs, whilst not having the expected negative effect.

Question 7

What negative effect can Dopaminergix drugs like levodopa have?

Answer 7

Dyskinesias (eg chorea)

Question 8

What negative effects can DA antagonists have?

Answer 8

Parkinsonism

Question 9

What conditions do SSRI’s treat

Answer 9

depression

Question 10

What do Gaba agonists treat?

Answer 10

epilepsy

anxiety (minor)