Applied Chemistry, Biochem, Physics

Question 1

Functional Groups: Ester

Answer 1

• (RCOOR)

Question 2

Functional Groups: Ether

Answer 2

• (ROR’)
• highly flammable
• halogen reduces flammability
• inert, do not react to oxidizing or reducing agents
• Halogenation alters blood solubility + potency

Question 3

Functional Groups: Amine

Answer 3

• (NR3)
• derivative of ammonia (NH3)
• 1 pair of electrons on the nitrogen

Question 4

Functional Groups: Alcohol

Answer 4

• (ROH)
• R represents any alkyl group (Alkyl = CnH2n+1)
• OH is highy polar + easily forms hydrogen bonds
• OH allows easy solubility in polar solvents

Question 5

Functional Groups: Phenol

Answer 5

• (ROH)

* similar to alcohol, however R represents an aryl group (benzene)

Question 6

Functional Groups: Aldehyde

Answer 6

• (RCHO)

Question 7

Functional Groups: Amide

Answer 7

• (RCONH2, RCONHR, or RCONR2)

Question 8

Functional Groups: Ketone

Answer 8

• (RCOR’)

Question 9

Functional Groups: Carboxylic Acid

Answer 9

• (RCOOH)

Question 10

local anesthetics are built from

Answer 10

3 components:

1. aromatic ring
2. intermediate chain
3. tertiary amine

Question 11

local anesthetic: aromatic ring does what?

Answer 11

confers lipid solubility

Question 12

local anesthetic: intermediate chain does what?

Answer 12

determines metabolism and allergic potential

Question 13

local anesthetic: tertiary amine does what?

Answer 13

confers water solubility (ionizes)

Question 14

Allergic reactions are more common in which local anesthetics?

Answer 14

ester based

Question 15

Which principle relates to the fact that an ascending aortic aneurysm may rupture if HTN occurs?

Answer 15

Law of LaPlace
T = Pr
(Tension = Pressure x radius)