Apolipoproteins

Question 1

Lipoproteins

A. Shape
B. Size
C. Composed?

Answer 1

A. Spherical
B. 10-1,200 nm
C. Apolipoproteins

Question 2

Classification (ultra centri)

Answer 2

Chylomicrons
VLDL
LDL
HDL

Question 3

Percentage

Chylomicrons
A. triglyceride
B. protein

Answer 3

A. 80-90%
B. 2%

Question 4

Percentage

VLDL
A. triglyceride
B. cholesterol
C. protein

Answer 4

A. 56-65%
B. 10%
C. 5-10%

Question 5

Percentage

LDL
A. triglyceride
B. cholesterol
C. protein

Answer 5

A. 10%
B. 50%
C. 25%

Question 6

Percentage

HDL
A. triglyceride
B. cholesterol
C. protein

Answer 6

A. 5%
B. 20%
C. 50%

Question 7

A. Amphipathic helix
B. Location

Answer 7

A. Apolipoproteins
B. surface of LPP

Question 8

A. Major protein on HDL
B. measure of …

Answer 8

A. Apo A1
B. Anti-atherogenic HDL (plasma)

Question 9

A. Large protein
B. Protein in …
C. Types (2)

Answer 9

A. Apo B
B. LDL, VLDL, Chylomicrons
C. Apo B-100 and Apo B-48

Question 10

A. LDL/VLDL; ligand (LDL receptor)
B. Chylomicrons

Answer 10

A. Apo B-100
B. Apo B-48

Question 11

A.
> LDL, VLDL, HDL
> Ligand (LDL receptor)
> Remnant receptor (chylomicron)
B. Types (3)

Answer 11

A. Apo E
B. Apo E2, Apo E3, Apo E4

Question 12

Major lipoproteins

Answer 12

Chylomicrons
VLDL
LDL
HDL

Question 13

Minor/Abnormal lipoproteins

Answer 13

IDL
LP (a)
LP X
Beta VLDL

Question 14

A. Turbidity of postprandial plasma
B. Contains?
C. Produced by?

Answer 14

A. Chylomicrons
B. Apo B-48
C. Intestine

Question 15

A. Turbidity in fasting hyperlipidemic
B. Contains?
C. Produced by?

Answer 15

A. VLDL
B. Apo B-100, Apo E3, Apo E4
C. Liver

Question 16

A. Consequence of lipolysis of VLDL
B. Contains?

Answer 16

A. LDL
B. Apo B-100, Apo E

Question 17

A. Smallest; most dense
B. Shape?
C. Produced by?

Answer 17

A. HDL
B. Disk-shaped / Spherical-shaped
C. Liver and Intestine

Question 18

A. Removing excess cholesterol from peripheral cells
B. HDL 2 and HDL 3

Answer 18

A. Discoidal HDL
B. Spherical HDL

Question 19

Reference range:

Total cholesterol

Answer 19

140-200 mg/dL (3.6-5.2 mmol/L)

Question 20

Reference Range:

HDL-C

Answer 20

40-75 mg/dL (1.0-2.0 mmol/L)

Question 21

Reference Range:

LDL-C

Answer 21

50-130 mg/dL (1.3-3.4 mmol/L)

Question 22

Reference range:

Triglyceride

Answer 22

60-150 mg/dL (0.7-1.7 mmol/L)

Question 23

Minor

A. Metabolism of VLDL - circulation
B. LDL particle to which Apo (a) linked Apo B-100 via disulfide bond

Answer 23

A. IDL
B. Lipoprotein (a)

Question 24

Abnormal

A.
With biliary cirrhosis/cholestasis
With familial lecithin / LCAT deficiency
B. Type 3 hyperlipoproteinemia

Answer 24

A. Lpx lipoprotein
B. B VLDL/Floating B

Question 25

Men/Women:

Total cholesterol
LDL
Triglyceride conc.

Answer 25

Elevated

Question 26

Young children:

Total cholesterol
LDL
Triglyceride

Answer 26

Decreased

Question 27

Abnormal lipid conc.
Genetic
Lifestyle imbalances
CHD

Answer 27

Dyslipidemia

Question 28

Heart disease
Increased LDL
Genetic

Answer 28

Hypercholesterolemja

Question 29

Intracellular cholesterol
Lack in active LDL receptors
Premature CAD

Answer 29

Familial Hypercholesterolemia

Question 30

Imbalance bet. synthesis/clearance VLDL
Life threatening (acute pancreatitis)

Answer 30

Hypertriglyceridemia

Question 31

Presence: elevated serum total cholesterol
Elevated CHD

Answer 31

Combined Hyperlipoproteinemia

Question 32

Increased CHD/CVD
Block plasminogen (clots along arterial wall)
Decreased lipoprotein conc.

Answer 32

Lp (a) elevation

Question 33

Decreased HDL conc. 1-2 mg/dL (0.03-0.05 mmol/L)
Tangier disease
Total chole 50-80 mg/dL (1.3-2.1 mmol/L)
Mutations: ABCA1gene

Answer 33

Hypoalphalipoproteinemia

Question 34

Decreased LDL and Apolipoprotein B

Answer 34

Hypobetalipoproteinemia

Question 35

LCAT

A.
Corneal clouding
Nephropathy
Hemolytic anemia
HDL

B. Fish-eye

Answer 35

A. Complete (homozygous)
B. Mild (heterozygous)