APLS Flashcards
1
Q
Clinical criteria
A
Vascular thrombosis Pregnancy morbidity Recurrent miscarriage SB PET/IUGR with del <34 weeks
Need one of these and an antibody
2
Q
Antibodies
A
Anti-b2 glycoprotein antibodies
Anticardiolipin antibodies
Lupus anticoagulant
3
Q
APLS presence in SLE and miscarriage
A
20-30% SLE
Recurrent miscarriage 15%
4
Q
Maternal features
A
VTE arterial embolism Thrombocytopenia Haemolytic anaemia Livedo reticular is
5
Q
Fetal
A
SB PET IUGR Recurrent miscarriage Preterm birth
6
Q
Pathogens is
A
All activating platelets, endothelial cells, monocytes __> thrombosis
APL interfere with anticoagulant shield on phospholipid expressing surfaces—>thrombosis
Inflamm response on trophoblastic —>apoptosis_->abnormal placentation
7
Q
Treatment
A
Aspirin and clexane prophylaxis
Reduce recurrent miscarriage risk
Late complications no big difference
8
Q
PET prior to 34 weeks
A
Need screening for APLS
