Aplastic anemia Flashcards
1
Q
What are causes of aplastic anemia?
A
Hereditary: Fanconi’s anemia, others
Acquired:
Direct toxicity: radiation, chemo drugs, toxins like benzene
Indirect toxicity (prob immune): idiopathic, drugs like chloramphenicol, infections (TB, HIV, EBV, CMV, etc), pregnancy
unknown: Paroxysmal nocturnal hemoglobinuria
2
Q
What is the basic mechanism behind aplastic anemia?
A
Suppression or death of common myeloid progenitor cell
3
Q
What are the two major causes of death in aplastic anemia?
A
infection or bleeding out (low platelets, and they don’t transfuse well)
4
Q
What is the therapy for aplastic anemia?
A
Bone marrow transplantation and Antithymucyte globulin (ATG) together. ATP is an suppressant to suppress own immune response against transplant
