Aplastic anaemia Flashcards
1
Q
Aplastic anaemia?
A
- Characterised by pancytopaenia and a hypoplastic bone marrow
- Peak incidence of acquired = 30 years old
2
Q
Features?
A
- normochromic, normocytic anaemia
- leukopenia, with lymphocytes relatively spared
- thrombocytopenia
- may be the presenting feature acute lymphoblastic or myeloid leukaemia
- a minority of patients later develop paroxysmal nocturnal haemoglobinuria or myelodysplasia
3
Q
Causes?
A
- idiopathic
- congenital: Fanconi anaemia, dyskeratosis congenita
- drugs: cytotoxics, chloramphenicol, sulphonamides, phenytoin, gold
- toxins: benzene
- infections: parvovirus, hepatitis
- radiation
4
Q
A
