APIC Flashcards

(49 cards)

1
Q

What receptor are neuromuscular blockade drugs specific for?

A

nicotinic acetylcholine receptor

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2
Q

Where does the trachea begin?

A

At the level of the thyroid cartilgae C6

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3
Q

What level dose the trachea bifrucate

A

T5

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4
Q

When to suspect difficult bag mask ventilation

A
BONES
Beard
Obesity/ Obstetrics 
No teeth
Elderly
Sleep Apnoea
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5
Q

Proper positioning for intubation

A

“sniffing position” : flexion of lower C spine (C5,6), i.e bow head forward and extension of upper C spine at atlanto (C1) - occipital joint, ie. nose in the air

aligns the 3 axes of mouth, pharynx and larynx to allow visualisation from the oral cavity to the glottis
proper position for laryngoscope tip to visualise cords is in the epiglottic vallecular
contraindicated in known/ suspected C spine fracture/ instability

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6
Q

Differential Diagnosis of Poor bilateral breath sounds after Intubation

A
DOPE
Displaced ETT
Obstruciton
Pneumothorax
Esophageal intubation
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7
Q

ASA Classfication

A

1: Normally healthy
2: Mild systemic disease, but with no limitation of activity
3: Severe Systemic disease that limits activity; not incapacitating
4: Incapacitating systemic disease which poses a threat to life
5: Moribund. Not expected to survive 24 hour even with operation
6: Braindead patient whose organs are being removed for donor purposes

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8
Q

State which stage of anesthesia each of the following descriptions refers to? Delirium; violent behavior; increased blood pressure; increased respiratory rate; irregular breathing
rate and volume; amnesia; retching and vomiting with stimulation; disconjugate gaze

A

Stage II (excitement)

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9
Q

State which stage of anesthesia each of the following descriptions refers to? Depression of vasomotor center; depression of respiratory center; death may occur

A

Stage IV (medullary depression)

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10
Q

State which stage of anesthesia each of the following descriptions refers to? Eye movements cease; fixed pupils; regular respiration; relaxation of skeletal muscles

A

Stage III (surgical anaesthesia)

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11
Q

State which stage of anesthesia each of the following descriptions refers to? Loss of pain sensation; patient is conscious; no amnesia in early part of this stage

A

Stage I (analgesia)

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12
Q

Give Examples of inhaled anaesthetics

A

sevoflurane; desflurane; nitrous oxide;

isoflurane; enflurane; methoxyflurane Halothane;

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13
Q

With regard to inhaled anesthetics, what does MAC stand for?

A

minimum alveolar concentration

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14
Q

What is MAC in regard to inhaled anesthetics?

A

The concentration of inhaled anesthetic required to stop movement in 50% of patients following a surgical stimulus; a measure of potency for inhaled anesthetics

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15
Q

Which inhaled anaesthetic has the largest MAC?

A

Nitrous oxide

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16
Q

Which inhaled anaesthetic has the smallest MAC

A

Halothane

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17
Q

As lipid solubility of an inhaled anesthetic increases, what happens to the concentration of inhaled anesthetic needed to produce anesthesia, that is, does it increase or decrease?

A

Decreases

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18
Q

What is the blood/gas partition coefficient?

A

The ratio of the total amount of gas in the blood relative to the gas equilibrium phase. It refers to an inhaled anesthetic’s solubility in the blood.

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19
Q

Are MAC values higher or lower in elderly patients

A

Lower

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20
Q

Are MAC values higher or lower when opioid analgesics and/or sedative hypnotics are used concomitantly?

21
Q

What is the role of the periaqueductal gray matter?

A

Primary control centre for descending pain modulation

22
Q

enkephalin?

A

endogenous opiod neurotransmitter

23
Q

Substantia gelatinosa

A

where the first order neuron of the spinothalamic tract synapses n

24
Q

Do inhaled anesthetics increase or decrease the response to Pco2 levels?

25
what characterises malignant hyperthermia?
Hyperthermia; muscle rigidity; acidosis; hypertension; hyperkalemia
26
Should a patient with a family history positive for malignant hyperthermia be concerned?
Yes, because a genetic defect in ryanodine receptors may be inherited.
27
What inhaled anaesthetic can cause hepatotoxicity
Halothane
28
What inhaled anaesthetic can cause nephrotoxicity?
Methoxyflurane
29
Which inhaled anaesthetic can be a proconvulsant
Enflurane
30
What inhaled anaesthetic can cause expansion of gas inside a closed body cavity
Nitrous oxide
31
What does thiopental do to cerebral blood flow
Decreases it
32
What does ketamine do to cerebral blood flow
Increases it
33
Why is more local anaesthetic needed in infected tissue?
Infected tissue has low ph | Anaesthetics become charged and cannot cross the membrane effectively
34
What is the order of sensory loss with local anaesthetics
Pain, temperature, touch, pressure
35
Which local anaesthetic can cause severe cardio toxicity
Bupivacaine
36
Which local anaesthetic can cause arrhythmias
Cocaine
37
What do you use to treat malignant hyperthermia
Dantrolene
38
Mechanism of succinylcholine
Strong Ach receptor agonist
39
Mechanism of Dantrolene
Prevents the release of calcium from the sarcoplasmic reticulum of skeletal muscle
40
What is the mechanism of non depolarising neuromuscular blocking drugs
Competitive antagonist of AcH receptor
41
Name the non depolarising neuromuscular blocking drugs
Rocuronium, mivacurium, vecuronium, tubocurarine, pancuromium
42
Complications of succinylcholine
Hypercalcemia, hyperkalemia, malignant hyperthermia
43
Describe the phases of succinylcholine in neuromuscular blockade
Phase 1: prolonged depolarisation | Phase 2: repolarised but desensitised
44
Side effects of local anaesthetic
CNS excitation Hypertension Hypotension
45
Describe how tertiary amine local anaesthetics act on sodium channels
Penetrate membrane in the uncharged form then bind to ion channel in charged form
46
What is malignant hyperthermia?
hypermetabolic disorder of skeletal muscle  due to an uncontrolled increase in intracellular Ca2+ (because of an anomaly of the ryanodine receptor which regulates the Ca2+ channel in the sarcoplasmic reticulum of skeletal muscle)
47
Inheritance of malignant hyperthermia
Autosomal dominant
48
What drugs can trigger malignant hyperthermia?
All inhalational agents except NO | Muscle depolarising agents - Sch
49
Signs of malignant hyperthermia
``` unexplained rise in ETCO2 increase in minute ventilation tachycardia rigidity  hyperthermia (late sign) ```