APA 2 - GI Disturbances and Anesthesia Flashcards
The process of digestion begins with __________
mastication
Local and general anesthesia depress sensation of the _____ ______ innervation
upper airway
Trigeminal nerve
nasopharynx
glossopharyngeal nerve
posterior third of tongue and oral pharynx
SLN
tongue base and inferior epiglottis to the vocal cords
RLN
vocal cords distally
Branches of vagus nerve
remaining larynx and trachea
Pathology such as pharyngeal tumor, CVA and metabolic toxins increase the reisk of periopertive inability to handle ________ and puts the patient at risk for aspiration pneumonia
secretions
Originates at the pharynx at approximately the level of the 6th cervical vertebra and extends to the stomach
esophagus
3 functional zones of esophagus
Upper Esophageal Sphincter, Esophageal body, Lower Esophageal sphincter
Typically, the sphincters hold tight but with _______ _______ can cause sphincter relaxation and higher risk of aspiration
anesthesia induction
Cricoid cartilage is at about
C6
Esophageal wall consists of outer longitudinal layer, inner circular ______ ______, and ______ lining
muscular layer / mucosal
Inner circular muscular layer consists of ____ and ______ muscle
smooth and striated
Mucosal lining has _______ epithelium, except for distal 1-2cm which is composed of _________ epithelium
squamous / columnar
The esophagus passes through a space creagted by the ____ _____ of the diaphragm
right crus
The esophageal wall is ______ absorptive
highly
The myenteric plexus of Auerbach is mainly a __________ (vagus nerve) plexus along with some postganglionic ______ nerves
parasympathetic / sympathetic
The inferior thyroid arteries supply the _____ ______
cervical esophagus
Aorta esophageal branches of bronchial arteries supply the ______ _______
thoracic esophagus
Intrinsic innervation is provided by the myenteric or _______ plexus and the submucosal or ________ plexus
Auerbach / Meissner
The intrinsic innervation extends from the esophagus to the _______
anus
Extrinsic innervation is provided by the ________, _______ and _______
sympathetic / parasympathetic / somatic
Extrinsic sympathetic innervation acts on _______ plexus to modulate rather than control motor activity
myenteric
Extrinsic parasympathetic innervation involves cranial nerves ___, ____, _____ and causes esophatgeal muscular relaxation as well as relaxation of the ______
IX / X / XI / LES
Both the UES and LES are _____ at rest
closed
Excitatory stimulation of the UES occurs due to (5)
inspiration, esophageal distention ,gagging, valsalva maneuver, acidity of gastric contents
UES tone is reduced by (3)
distention, belching, vomiting
Swallowing initiates peristalsis that has average velocity of ____ cm/sec and a maximum pressure of _____mmHg
3-4 cm/sec AND 150 mmHg
Swallowing decreases _______ within 1.5-2.5 sec, this decrease in tone is maintained for the duration of the peristaltic wave
LES
ingestion of meal or increased abdominal pressure _________ LES tone via _______ afferent pathways
increases / vagal
Normal LES tone is ______mmHg and can be _________
20 / overcome
Normal LES is mediated by intrinsicc ____ and excitatory nerual mechanisms. __________ innervation is predominant
myogenic / vagal
With chronic alcoholism you will see what 4 things
impaired esophageal peristalsis, LES HYPOTONIA, Degeneration of the auerbach plexus, mallory weis tear
Failure of the LES tone to relax during swallowing accompanied with a lack of perstalsis
achalasia
Achalasia develops secondary to what chronic diseases
diabetes, stroke,amyotrophic lateral sclerosis, connective tissue diseases (amyloidosis and scleroderma)
With Barrett Esophagus, normal squamous epithelium changes to ________ __________ epithelium
metaplastic columnar epithelium
Barrett esophagus causes
chronic exposure to acidic gastric contents (GERD), chronic alcohol abuse, smoking
Barret esophagus is closely associated with eventual development of _______ ________
esophageal carcinoma
GERD is from failure of the _______ to function properly permitting stomach contents to reflux into the esophagus and possibly the pharynx
LES
Current mangagment modality for GERD
PPIs and H2 antagonists
This happens due to a weakness in the diaphragm that allows a portion of the stomach to migrate upward into the thoracic cavity
hiatal hernia
Primary symptoms of hiatal hernia include ________ pain of a burning quality that commonl occurs after meals, peptic esophagitis and it is treated _______
retrosternal / surgically
Review types of hiatal hernia on slides
27 and 28
Most common surgical procedure for hiatal hernia
nissen fundoplication
Esophageal diverticula are classified according to ______
location
Epiphrenic
locared near the LES
Traction
located mid-esophagus
Zenker
locared upper esophagus
Esophageal diverticula place the patient at risk for pulmonary aspiration of regurgitated food and also from food/fluids ingested but sequestered within ________
pouch
With Esopahgeal malignancy, the patient may have had preoperative radiation which can result in bone marrow suppression, intrathoracic and pulmonary ________ and increased friability of tissues
fibrosis
Daunorubicin and doxorubicin/adriamycin both can cause chemotherapyy induced _________
cardiomyopathy
Bleomycin can cause ________ _______ which results in a restrictive defect and increased potential for ____________ toxicity
pulmonary fibrosis / oxygen
A history of GERD with active reflux symptoms warrants a plan for _________ prophylaxis during _________ and __________ from general anesthesia
aspiration / induction / emergence
Esophageal disease mandates use of a ___________ _________ to create a sealed airway to prevent risk from passive regurgitation and aspiration
endotracheal tube
Someone with esophageal disease should be fully _______ and have demonstrated conscious control of the airway prior to extubation
awake
Esophageal cancer surgery Ivor-Lewis Repair
Anterior abdominal incision and right thoracotomy
Esophageal cancer surgery Ivor-Lewis McKeown - type
right neck incision, excision of diseased esophagus, anastamosis of stomach to cervical esophagus
If weight loss has exceeded ____%, enteral nutrition comprising of at least ________kcal/day of a high protein liquid diet should be administerd at least _____ days before surgery
10 / 2000 / 10
_______ ___________ should always be corrected preoperatively
aspiration pneumonia
Esophageal resection is associated with various inratoperative complications (3)
hemorrhage, injury to the tracheobronchial tree, RLN injury
Esophagela resection postopervie complications
anastomotic leak, mediastinitis, respiratory problems, pleural effusion, pneumonia, and ARDS, cardiac and functional complications
Postoperative _____ ______ is not uncommon in patients undergoing curative resection for esophageal cancer and can be categorized as either locoregional or distant.
tumor recurrence
______ _________ most commonly involve the liver, lungs and bones followed by the adrenal glands, brain and kidneys and may involve multiple organs simultaneously
hematogenous metastases
Intraoperative complications include ________ and ____________, hemorrhage, injury to the tracheobronchial tree and injury to the RLN
arrhythmias and hypotension
Injuries to the RLN can imparit the ability of the patient to _______ and can cause aspiration pneumonia.
cough
With the recent advancement of extended lymphadenectomy in esophageal cancer surgery, accurate disection of lymph nodes along the _______ chains and preseration of these nerves are important surgical issues
RLN
Look at slide
49 (RLN)
Regardless of surgical technique used, esophageal resection is a high-risk procedure associated with considerable _______ and ________. With improvements in techniques, there has been a decrease from 12% in the 1970s to ____% in the late 1980s and 1990s.
morbidity and mortality / 3%
Morbidity and mortality rates vary greatly depending on the surgical volumes, hospital size and degree of ________ specialization
cancer
Most serious complications of esophageal resection
anastomotic leak, mediastinitis, sepsis and respiratory failure
Two sections of the stomach
fundus and distal stomach
Fundus of stomach is _____walled, distendable, located in the _______ abdomen and primary function is ________ (4hrs)
thin / upper / storage
The distal stomach is ______ wallled, this is where mixing of food occurs, and slow relesase of _____ through _____ ______ into the duodenum
thick / chyme / pyloric sphincter
The stomach is located in the uppr part of the abdomen just beneath the ______
diaphragm
An empty stomach is roughly the size of an ______ _____. It can fill much of the upper abdomen when distended with food and may descend into the _____ _____ or pelvis upon standing
open hand / lower abdomen
The duodenum extends from the _______ to the ligament of ______ in a sharp curve that almost completes a circle
pylorus / treitz
The duodehum is eaual in length to the breadth of 12 fingers or about _____ cm
25 cm
The duodenum is largely __________ and the position is relatively _______. The stomach and duodenum are closely related in function and in pathogenisis and manifestation of disease
retroperitoneal / fixed
The serosa is the ______ _______ of the gastric wall and. The three smooth muscle layers are?
external layer / outer longitudinal, middle circular, inner oblique
The anatomy of the gastric wall from exgternal to internal
Serosa -> muscularis mucosae (smooth muscle) -> submucosa -> mucosa
acid secretion of _____ ______ requires a hydrogen/potassium exchange pump pwered by _____
parietal cells / ATP
Acid release is mediated by vagal stimulation (Ach), _______ release (in response to gastric distension) and histamine
gastrin
Many of our reversal medications will increase the amount of ______ available at all receptor sites, resulting in lots of GI stimulation (salivation, urination, defecation, gastric contents)
Acteylcholine
Within the gastric mucosa reside the glands responsible for the physiologic role of the stomach during digestion. The fundic mucosa has mucus-secreting glands that provide a protective barrier to the acid outflow of ______ ______
parietal cells
The sight and smell of food stimulates ____ and ______ production
acid / pepsinogen
Gastrin is released by __ cells in response to ______ ________ which stimulates parietal-cell acid secretion
G / gastric distension
_______ acid suppresses gastric fedback (negative feedback)
luminal
Anticholinergic agents have a minor (not therapeutic) effect on ______ ______ secretion
parietal cell
What surgery can be done to control gastric acid secretion
Vagotomy
A vagaotomy diminishes parietal cell response to ______ and _______
gastrin and histamine