AP patterning and organogenesis Flashcards
1
Q
somites
A
transient blocks of tissue, and eventually give rise to the bone and cartilage of the trunk, to the skeletal muscles and to the dermis of the skin.
2
Q
Paraxial mesoderm
A
ventral-lateral mesoderm, on each side of the notochord.
3
Q
Pre-somitic mesoderm
A
between most recently formed somites and the node; the length of the pre-somatic mesoderm remains more or less constant.
4
Q
Signalling pathways involved in somite formation
A
- Wnt, Nodal and BMP
- Fibroblast growth factor (FGF)
- Retinoic Acid (RA)
5
Q
Vertebrae: somite-derived structure. Patterning controlled by Hox gene expression?
A
- Cervical = neck
- Thoracic = mid back
- Lumbar = lower back
- Sacral = sacrum (heiligbeen)
- Caudal = tailbone
6
Q
Gene expression pattern of Hoxa3 and Hoxd3 during AP patterning are
similar: both expressed in the….
A
vertebrae, neural tube, branchial arches and paraxial mesoderm.
7
Q
hox genes are located in …., targetted by ….. signalling
A
nucleus, Retinoic Acid (RA)
