AOT

Question 1

AOT is done prior to?

Answer 1

In vitro test

Question 2

AOT is done in order to establish first?

Answer 2

How much drug will be given

Question 3

Killing the animals in the first dose is

Answer 3

Not economical and unethical

Question 4

If the test often is not characterized, we conduct?

Answer 4

AOT

Question 5

What method is conducted in the laboratory and an original way to conduct AOT?

What does it employ?

Answer 5

Classical method

Probit analysis-used to determine LD50

Question 6

OECD 420 is also known as

Answer 6

Fixed dose procedure

Question 7

OECD 423 is also known as

Answer 7

Acute toxic class method

Question 8

OECD 425 is also known as

Answer 8

Up and down procedure

Question 9

It refers to the adverse effects following oral administration within 24 hours

Answer 9

AOT

Question 10

Animal did not die or appear moribund within 48 hours but died on the 14 day observation

Answer 10

Delayed death

Question 11

The amount of test substance administered
Weight of test/weight of animal

Answer 11

Dose

Question 12

Aka dose spacing factor
A dose is increased if survived and decrease if died

It is recommended to be

Answer 12

Dose progression factor

3.2= antilog 0.5 or 1/2

Question 13

GHS meaning and a joint activity of

Answer 13

Globally harmonized classification system

OECD (human health and environment)
UN committee of experts on transport of dangerous goods (physical-chemical properties)
ILO (Hazard communication)
Coordinated by interorganizational program for the sound management of chemicals

Question 14

Moribund state or death is expected

Signs indicative of this state

Answer 14

Impending death

Convulsions
Lateral position
Recumbence
Tremor

Question 15

Expected to cause death in 50 percent of animals

Also known as

Answer 15

LD50

Median lethal dose

Question 16

Dose at an upper limitation on testing

Answer 16

Limit dose

Question 17

State of dying or inability to survive even when treated

Answer 17

Moribund status

Question 18

Total number of tested animals

Answer 18

Nominal sample size

Question 19

Presence of clinical signs indicative of death at a known time

Answer 19

Predictable death

Question 20

Probit is an abbreviation for the term

Answer 20

Probability integral transformation

Question 21

Permits a standard normal distribution of expected responses

Answer 21

Standard normal distribution

Question 22

A standard lethal normal distribution is?

It’s mean is also it’s?

Answer 22

Symmetric

True LD50 or median response

Question 23

Non responsive is observed at some dose and a response is observed at the next

Answer 23

Reversal

Question 24

A log normal curve describing the range of tolerances to chemical

Answer 24

Standard deviation

Question 25

Value related to the angle at which the dose response curve rises from the dose axis

Answer 25

Slope of the dose response curve

Question 26

Slope of probit analysis

Answer 26

Straight line and slope is the reciprocal of standard deviation

Question 27

Determines when a testing sequence terminates

Relies on

Answer 27

Stopping rule

Comparison of ratios

Question 28

Intervals are commonly

Answer 28

0.4-0.6

Question 29

What to do to know the effect of the year item in the organs

Answer 29

Organ in formalin —> Histopathology to see cellular damage

Question 30

Who reviews experimental researched
What do they recommend

Answer 30

IACUC(Institutional Animal Care and Use Committee)
OECD

Question 31

What method is commonly used for chemicals

Answer 31

OECD

Question 32

It is starting the dose according to the previous study

Answer 32

Sighting study

Question 33

What does limit test mean

Answer 33

At 2000 mg/kg = no death= LD50

Question 34

What method uses a lot and lesser animals

Answer 34

OECD: lesser
Classical: alot

Question 35

Aims of AOT

Answer 35

Signs of toxicity
Establish LD50
Target organ toxicity