Aortic aneurysm, acute and chronic ischaemia Flashcards
what is an abdominal aortic aneurysm?
a permanent pathological dilation of the aorta with a diameter >1.5x the expected anterior posterior diameter of that segment.
most commonly adopted threshold is >3cm
where are most AAA’s located ?
90% below the level of the renal arteries
what are the S&S of AAA?
asymptomatic
palpable, pulsatile, expansile abdominal mass
how are suspected AAA’s investigated?
abdo US
follow up CT scan with contrast if >5.5cm
how are AAA’s managed ?
- 0 – 4.4cm: yearly ultrasound
- 5 – 5.4cm: 3-monthly ultrasound
Medical
- Smoking cessation
- Improve blood pressure control
- Commence statin and aspirin therapy
- Weight loss and increased exercise
Surgical
- Open repair involves a midline laparotomy or long transverse incision, exposing the aorta, and clamping the aorta proximally and the iliac arteries distally, before the segment is then removed and replaced with a prosthetic graft
- Endovascular repair involves introducing a graft via the femoral arteries and fixing the stent across the aneurysm
what are the S&S of a ruptured AAA?
sudden, severe onset epigastic pain and/or back/loin pain
sudden collapse
Hx of AAA
rapid onset hypotension, pain and sweating
what is the emergency management of ruptured AAA?
call for senior and anaesthetist permissive hypotension IV access, cross match, order FFP and platelets modest analgesia (morphine 5-10mg) straight to threatre ABx prophylaxis aortic cross clamping distal anastamoses
what causes acute limb ischaemia?
acute thrombosis in vessel with pre-existing atherosclerosis (60%)
Emboli (30%)
rare causes
- aortic dissection
- intra arterial drug use
- trauma
what are the S&S of acute limb ischaemia ?
Pain Pallor Pulselessness Paraesthesia Paralysis Perishingly cold
How is acute limb ischaemia classified?
The Rutherford classification
Stage 1 = limb not immediately threatened
- no sensory loss or muscle weakness - pedal and popliteal arteries audible on doppler
Stage 2a = limb marginally threatened
- minimal sensory loss, no muscle weakness - popliteal arteries audible, pedal not
Stage 2b = limb immediately threatened
- pain at rest, moderate muscle weakness - popliteal audible, pedal not
Stage 3 = limb irreversibly damaged
- profound pain, muscle paralysis - popliteal and pedal inaudible
what are the InV done in acute limb ischaemia?
Duplex/doppler US ECG - look for AF Basic bloods Lactate - assess ischaemia CT/MR angiography to guide revascularisation
what is the management of acute limb ischaemia ?
initial
- emergency assessment by vascular surgeon
- systemic anticoagulation with heparin
- paracetamol and morphine
Surgical
- revascularisation via thrombectomy or embolectomy. Percutaneous catheter directed thrombolysis. Bypass graft surgery
- amputation
what are the complications of acute limb ischaemia ?
death in 15-20%
Reperfusion injury
- compartment syndrome (due to oedema)
- hyperkalaemia (due to K+ release)
- systemic acidosis from H+ release
- AKI
Peripheral nerve injury (leading to chronic neuropathic pain)
what is compartment syndrome?
Compartment syndrome is a pathological condition characterised by elevated interstitial pressure in a closed osteofascial compartment that results in microvascular compromise (restriction of capillary blood flow)
what causes compartment syndrome?
Elevated interstitial pressure in a closed osteofascial compartment may be secondary to several different factors. Haemorrhage within the compartment or direct trauma to the muscles with subsequent oedema can lead to increased pressure to above the capillary level, which restricts capillary flow. This results in tissue necrosis secondary to oxygen deprivation.
what are the S&S of compartment syndrome?
pain (out of proportion)
muscle tightness
paraesthesia
pulselessness, pallor and paralysis
what InV are done in compartment syndrome?
compartment pressure measurement
- intra-compartment pressure of >30mmHg
- delta pressure <30mmHg
serum creatinine kinase eleavted
urine myoglobin elevated
what is the treatment of compartment syndrome?
dressing release
morphine
fasciotomy
amputation
what is chronic limb ischaemia?
peripheral arterial disease that results in symptomatic reduced blood supply to the limbs
typically caused by atherosclerosis and affects the lower limbs
how is lower limb ischaemia classified?
the Fontaine classification
I = asymptomatic II = intermittent claudication III = rest pain IV = ulcers/gangrene
what are the risk factors for chronic limb ischaemia?
smoking
DM
HTN
hyperlipidaemia
what are the clinical features of chronic limb ischaemia?
intermittent claudication
- calf pain on exertion
- worse on sitting/lying and eleviated by standing
ischaemic lesions or gangrene
pale and cold limbs
weak or absent pulses
limb hair loss, skin changes and thickened nails
what are the differentials of chronic limb ischaemia?
spinal stenosis (neurogenic claudication)
Nerve root compression (sciatica)
Acute limb ischaemia
what is chronic limb ischaemia investigated?
ABPI
- Normal = >0.9
- Mild = 0.8-0.9
- Moderate = >0.5-0.8
- Severe = <0.5
Buerger’s test
- angle less than 20 degrees = severe ischaemia
Doppler US
CT/MR angiogram
FBC, lipids and glucose
what are the drawbacks of ABPI?
calcifications of arteries can give falsely high ABPI
how is chronic limb ischaemia managed?
lifestyle advice
- smoking cessation
- exercise (helps form collaterals)
- decrease weight, low fat diet
Statin
antiplatelet
angioplasty and stenting
Bypass grafting
Amputation (for gangrenous)
what are the complications of chronic limb ischaemia?
sepsis (secondary to infected gangrene)
Acute-on-chronic ischaemia
amputation
death in critical limb ischaemia