Anythelmintics

Question 1

Levamisole

Answer 1

Hyper contraction - spastic paralysis
Agonist of acetylcholine receptors at neuromuscular junction
Causes depol so contraction

We’ll tolerated but nausea and dizziness as activates Nicotinic receptors in basal ganglia

Question 2

Piperazine

Answer 2

Marketed: pripsen for thread worm
Flaccid paralysis of nematodes (ascariasis)
Partial agonist of GABAA receptor so competitive antagonist activity causing. Hyperexcitability

SEIZURES IN THOSE WITH EPILEPSY

Question 3

Ivermectin

Answer 3

Treats riverblindness and ascariasis
Positive allosteric modulator of glutamate gated chloride channel (gluchloride alpha)
Hyperpol through opening chloride channels causing inhibition

Effects: paralysis, inhibits feeding and reproduction

Selective - mammals don’t have glutamate gated chloride channels

Question 4

Emodepside

Answer 4

New gen targeting k channels
Resistance breaking
Slows development, inhibits locomotion, feeding and egg laying

Slo1 = calcium activated potassium channel. Regulates excitability in muscle neurones
Agonist - activates channel, efflux of k out, inhibiting cell activity

Question 5

Amino- aceto- nitride dervatives

Answer 5

New generation
Resistance breaking
Nicotinic acetylcholine receptor
Inhibits motility

Isoform only found in worms