Anxiolytics

Question 1

Benzodiazepines

Answer 1

• Clonazepam
• Alprazolam
• Lorazepam
• Diazepam

Positive allosteric modulators of GABA
• E.g. Diazepam potentiates GABA-induced hyperpolarization.
o Open state frequency increases.
o Open duration increases.

Question 2

5-HT1A Agonists

Answer 2

• Buspirone

* Ipsapirone

Question 3

SSRIs

Answer 3

• Fluoxetine
• Escitalopram
• Paroxetine

Question 4

SNRIs

Answer 4

• Venlafaxine

* Duloxetine

Question 5

Beta-Adrenoceptor Antagonists

Answer 5

• Propranolol

Reduce action of sympathetic system to allow sleep.