Anxiolytics

Question 1

What are the four categories of symptoms for anxiety disorders?

Answer 1

-Apprehension
-Vigilance
-Motor tension
-Autonomic hyperactivity (sympathetic NS activation)

Question 2

What is the onset of obsessive compulsive disorder?

Answer 2

-Onset occurs in early childhood

Question 3

What are the side effects of benzodiazepines?

Answer 3

-Sedation, ataxia, confusion, cognitive/motor impairment, amnesia
-Especially problematic in children/adolescents and elderly
-Some evidence that impairments are semi-permanent*
-High liability for tolerance/dependence/abuse

Question 4

What are serotonin receptor agonists?

Answer 4

-SSRIs which have anti-depressant and anxiolytic effects
-It is the first choice for anxiety disorders which are well tolerated and have high safety
-SSRIs are especially good for OCD and PTSD while BZDs are not*

Question 5

In addition to treating anxiety, Buspirone can be used to improve the ________________ side effects caused by SSRIs.

Answer 5

Sexual

Question 6

Alprazolam is contraindicated in patients who _______.

Answer 6

Smoke

Question 7

Compared to barbiturates, benzodiazepines are ______.

Answer 7

Safer

Question 8

Barbiturates and benzodiazepines bind to what kind of receptor?

Answer 8

GABAA

Question 9

Of the following anxiety disorders, which one has equal gender ratios?

Answer 9

Social anxiety

Question 10

Compared to benzodiazepines, SSRIs seem to be particularly effective for treating
_____.

Answer 10

OCD

Question 11

Propanolol is a ______.

Answer 11

Beta blocker

Question 12

Which of the following neurotransmitters is NOT thought to be important to the etiology of anxiety?

Answer 12

Dopamine

Question 13

Barbiturates are in a class of drugs known as

Answer 13

Sedative-hypnotics

Question 14

Venlafaxine is associated with a higher risk of ___________ in young (<24) patients.

Answer 14

Suicide

Question 15

Benzodiazepines differ from one another mainly in terms of

Answer 15

Pharmacokinetics

Question 16

The most common sub-type of anxiety disorder is

Answer 16

Phobia

Question 17

Stimulation of the GABAA1 receptor is thought to result in all the following effects EXCEPT

Answer 17

Anxiolysis

Question 18

The most common cause of death when combining benzodiazepines with another CNS depressant (like alcohol) is ______.

Answer 18

Respiratory depression

Question 19

The anticipatory anxiety experienced by people who have panic attacks can sometimes progress to ______.

Answer 19

Agoraphobia

Question 20

Drugs that reduce the activity of the _____________ seem to be particularly efficacious for treating Panic Disorder.

Answer 20

Locus coeruleus

Question 21

Which of the following is NOT a common obsessive behavior seen in patients with OCD?

Answer 21

Cartwheeling

Question 22

Which of the following is NOT a benefit of Buspirone?

Answer 22

It is immediately effective

Question 23

Unlike other anxiolytics, beta-blockers primarily work:

Answer 23

Peripherally

Question 24

The cortical hyperactivity seen in patients with anxiety disorders is thought to be due to all of the following EXCEPT:

Answer 24

DA hypofunction

Question 25

Which of the following is NOT a concern regarding barbiturates?

Answer 25

Some have extremely long half-lives

Question 26

What is the leading cause of PTSD?

Answer 26

Automobile accidents