Anxiety Disorders Flashcards

1
Q

Generalized Anxiety Disorder

A

Uncontrollable excessive anxiety or worry about multiple activities or events that leads to significant impairment or distress. Clinical onset usually in early 20s. Male-to-female is 1 to 2.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

History and physical for GAD

A

Presents with anxiety on most days (6 or more months) and with 3 or more somatic symptoms (restlessness, fatigue, difficulty concentrating, irritability, muscle tension, disturbed sleep)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Tx for GAD

A

A) Short term therapy

1) Benzo may help for immediate symptom relief
2) Taper benzos as soon as long term treatment is established (SSRI) in view of high risk of tolerance and dependence
3) Do not stop benzos abruptly as patients may develop potentially lethal withdrawal symptoms similar to those of alcohol withdrawal

B) Long term therapy

1) Lifestyle changes
2) Psychotherapy
3) Medications: SSRI (1st line), venlafaxine, buspirone (Just like SSRI, dont use buspirone with MAOIs)

PATIENT EDUCATION IS ESSENTIAL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

SSRIs as an anxiolytic

A

Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram

Indications: First line treatment for GAD, OCD and PTSD

Side effects: Nausea, GI upset, somnolence, sexual dysfunction, agitation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Buspirone

A

Can use as anxiolytic

Indications: GAD, OCD, PTSD

Side effects: Seizures with chronic use. No tolerance, dependence or withdrawal. HA. nausea. Dizziness.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

B- blockers as anxiolytics

A

Indications: Performance anxiety, PTSD

Side effects: Bradycardia, hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Benzos

A

Can be used as anxiolytics

Indications: Anxiety, insomnia, alcohol withdrawal, muscle spasm, night terrors, sleepwalking

Side effects: Reduced sleep duration; risk of abuse, tolerance and dependence; disinhibition in young or old patients; confusion. Respiratory depression.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Flumazenil

A

Competitive antagonist at GABA receptor

Indication: Antidote to benzo intox

Side effects: Resedation; nausea, dizziness, vomiting, and pain at injection site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Specifically when do you use flumazenil?

A

ONLY when either:

1) The OD is acute

AND

2) You are certain that there is no chronic dependence.

It can cause seizures in benzo-dependent patients. It causes acute withdrawal, which can be tremor or seizures similar to DT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

When do you use Lorazepam?

A

It’s used often in emergency situations bc it can be given IM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

When do you use Clonazepam?

A

It can be used if addiction is a concern given its longer half-life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

When do you use Chlordiazepoxide, oxazepam, lorazepam?

A

Used often in treatment of alcohol withdrawal. Lorazepam and oxazepam are the drugs of choice in patients with liver problems.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

When do you use alprazolam?

A

Used often in panic attacks and panic disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

When do you use flurazepam, temazepam, triazolam?

A

They are approved as hypnotics but are rarely used.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

OCD

A

Characterized by obsessions and/or compulsions that lead to significant distress and dysfunction in social or personal areas. Usually presents in later adolescence or early adulthood. Prevalence equal in men and women. Often chronic and hard to treat.

Many often present to nonpsychiatrist (may consult derm with a skin complaint secondary to overwashing hands)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

History and physical for OCD

A

1) Obsessions: Persistent, unwanted and intrusive ideas, thoughts, impulses, or images that lead to marked anxiety or distress (fear of contamination, fear of harm to oneself or to loved ones)
2) Compulsions: Repeated mental acts or behaviors that neutralize anxiety from from obsessions (hand washing, elaborate rituals for ordinary tasks, counting, excessive checking)
3) Patients recognize these behaviors as excessive and irrational products of their own minds (vs OCPD)
4) Patients wish they could get rid of the obsessions and/or compulsions

17
Q

Treatment of OCD

A

1) Pharm (SSRI***)
2) CBT using exposure and desensitization
3) Patient education!!!

TIP: If all answer choices are TCAs, pick clomipramine*

18
Q

OCD vs OCPD

A

1) OCD - characterized by obsessions and/or compulsions

Patients recognize* the obsessions/compulsions and want to be rid of them (ego dystonic)

2) OCPD - patients are excessively conscientious and inflexible.

Patients do not recognize their behavior as problematic (ego syntonic)

19
Q

What disorder often coexists with OCD?

A

Tourettes

20
Q

Panic Disorder

A

Characterized by recurrent, unexpected panic attacks. 2 to 3 times more common in women. Agoraphobia (fear of places where escape may be difficult/fear of being alone in a public place) is present in 30-50% of cases. The average onset is 25, but can happen at any age.

21
Q

History and exam for panic disorder

A

1) Panic attacks are defined as discrete periods of intense fear or discomfort in which at least 4 of the following symptoms (autonomic symptoms) develop abruptly and peak within 10 minutes:
a) tachypnea
b) chest pain
c) palpitations
d) diaphoresis
e) nausea
f) trembling
g) dizziness
h) fear of dying or “going crazy”
i) depersonalization
j) hot flashes
k) chills
l) parasthesias

2) Perioral and or acral parasthesias, when present are fairly specific to panic attacks, which produce hyperventilaton and low O2 saturation
3) Patients present with 1 or more months of concern about having additional attacks or significant behavior change as a result of the attacks -avoiding situations that may precipitate attacks

Usually last less than 30minutes and may be accompanied by agoraphobia

Make sure you determine if patient has PD with or without agoraphobia so you can address the agoraphobia in treatment plan

22
Q

Treatment of PD

A

1) Short term: Benzos (clonazepam) may be used for immediate relief, but long term use should be avoided in light of potential for addiction and tolerance. Taper benzos as soon as long term treatment is started (SSRI)
2) Long term - CBT. SSRIs are first line. Start with benzos and SSRI and taper off the benzo. Use CBT WITH meds not alone.

Alprazolam (Xanax) is a med sometimes used for PD, but patients can go into minor withdrawal within a day due to short half life

23
Q

Phobias

A

1) Social phobia/anxiety - characterized by marked fear provoked by SOCIAL or PERFORMANCE situations in which embarassment may occur. It may be specific (public speaking, urinating in public) or general (social interaction) and often begins in adolescence.
2) Specific phobia - anxiety is provoked by exposure to a feared object or situation. Most cases begin in childhood

24
Q

History and physical for phobias

A

Presents with excessive or unreasonable fear and/or avoidance of an object or situation that is persistent and leads to significant distress or impairment in function. Patients KNOW fear is excessive.

25
Q

Treatment of phobias

A

1) Specific phobias - CBT involving desensitization through incremental exposure to the feared object or situation along with relaxation techniques. Other options include supportive, family, and insight-oriented psychotherapy
2) Social phobias - CBT, SSRIs, low dose benzos, or B blockers (for performance anxiety) may be used.

Beta blockers such as atenolol or propranolol are used only for performance anxiety such as stage fright. They are given 30-60 minutes before the performance.

26
Q

PTSD

A

Follows exposure to an extreme, life threatening traumatic event (assault, combat, witnessing a violent crime) that evoked intense fear, helplessness or horror

top causes in men are rape (#1) and combat (#2).

Top causes in women are childhood abuse (#1) and rape (#2)

27
Q

History and physical for PTSD

A

1) Characterized by the following:
a) Reexperiencing of event (nightmares)
b) Avoidance of stimuli associated with the trauma
c) numbed responsiveness (detachment, anhedonia)
d) Increased arousal (hypervigilance, exaggerated startle) that leads to significant distress or impairment in functioning

2) Symptoms for at least 1 month
3) Survivor guilt, irritability, poor concentration, amnesia, personality change, sleep disturbance, substance abuse, depression, and suicidality may be present

28
Q

Tx for PTSD

A

1) Short term - To target anxiety; includes B blockers and alpha agonists (clonidine)

2) Long term
a) Meds: SSRIs are first line; buspirone, TCAs and MAOIs may be helpful. Benzos are also used by incidence of substance abuse among PTSD patients is high so use caution

b) psychotherapy and support groups

In ANY patient with history of substance abuse, avoid benzos

Summary of tx for PTSD: Paroxetine and sertraline. Prazosin is used to reduced incidence of nightmares. Psychotherapy for coping mechanisms and relaxation techniques/hypnosis.