Anxiety and Stress Disorders Flashcards
Anxiety - what is it?
● Anxiety is a normal emotion and common
reaction to the stress of everyday life.
● Diffuse, unpleasant, vague sense of
apprehension
● Becomes pathologic when functioning is impaired
Generalized Anxiety Disorder (GAD)
Generalized anxiety disorder (GAD) is characterized by excessive and persistent
worrying that is hard to control, causes significant distress or impairment, and
occurs on more days than not, for at least six months
Most common mental health disorder
GAD
Biological etiology of GAD
○ Norepinephrine, serotonin, and vanillylmandelic acid
are increased in patients with GAD
○ decreased postsynaptic alpha-2 adrenergic receptor
sensitivity
Medical conditions associated with GAD
○ Hyperthyroid
○ Cardiac arrhythmia
○ Asthma
○ Premenstrual Dysphoric disorder
GAD caused by medication side effects
○ Caffeine
○ Decongestants
○ Stimulants
○ Benzodiazepines
Review GAD DSM criteria in slides
slides 10-11
GAD- Clinical Presentation
● Restlessness or feeling keyed-up or on edge
● Being easily fatigued
● Difficulty concentrating or mind going blank
● Irritability
● Muscle tension
● Sleep disturbance
GAD - Screening tools
● GAD 7
● Hamilton Anxiety Scale
(HAM-A)
Complications & Risk Factors of GAD
● Associated with increased rates of substance abuse
● Common in patients presenting with medically unexplained Chronic pain
● Female sex
● Poverty
● Recent adverse life events
● Chronic physical illness (respiratory, cardiovascular, metabolic, cognitive),
● Chronic mental disorder (depression, phobia and past GAD)
● Parental loss or separation
● Low affective support during childhood
● History of mental problems in parents
GAD - Treatment
● Psychopharmacology
● Psychotherapy
● Other treatments
1st line treatment for Anxiety disorders is
● Psychotherapy
● SSRI
● Or both
Other Anxiolytics outside of SSRIs and SNRIs
○ Benzodiazepines
○ Buspirone
○ Hydroxyzine
○ Gabapentin
Benzodiazepine Mechanism of Action
● Target of action is the GABA receptor
● Gaba is the major inhibitory
neurotransmitter in CNS
● Binding of GABA to its receptor triggers opening of ION channel allowing Chloride ion influx
● Influx of chloride ion causes
hyperpolarization of the neuron and
decreases neurotransmission by inhibiting the formation of action potential
● Benzos increase frequency of channel
openings produced by GABA
Benzodiazepines
● Alprazolam (xanax)
● Clonazepam (klonopin)
● Diazepam (valium)
● Lorazepam (ativan)
● Temazepam (restoril)
● Chlordiazepoxide (librium)
Advantages of Benzodiazepines
● Work quickly
● Effective short term
Benzodiazepines Side effects
● Respiratory depression
● Daytime sedation
● Disinhibition
● Amnesia
● Physical and psychological
dependence
GAD - Psychotherapy
● CBT ( Cognitive Behavioral Therapy)
● Computerized CBT ( Fearfighter)
● Exercise
● Mindfulness
● Meditation