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PHAR 358 M1 > Anxiety > Flashcards

Anxiety Flashcards

1
Q

When does anxiety become a disorder?

A

overwhelming and affecting function and quality of life

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2
Q

2 main qualities of anxiety?

A

Fear and Worry

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3
Q

Psychological sx of anxiety?

A

fear
worry
apprehension
difficulty concentrating

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4
Q

Physical sx of anxiety?

A

Increased HR
Tremor
Sweating
GI upset

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5
Q

Amygdala centered sx?

A

Fear, panic, phobia

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6
Q

CSTC centered sx?

A

Worry, anxious misery, apprehensive, expectation, obsessions

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7
Q

Amygdala Characteristics?

A

Almond shaped near hippocampus
Interprets sensory and cognitive info and determines if there will be a fear response

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8
Q

CSTC regulated by?

A

COMT

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9
Q

GABA anxiety role?

A

role in anxiolytics
inhibitory NT that decreases activities of neurons

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10
Q

Voltage sensitive Ca channel subtypes?

A

N, P/Q

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11
Q

What drugs bind to the alpha2delta ligands of the N and P/Q VSCCs?

A

Pregabalin
Gabapentin

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12
Q

What does binding of the alpha2delta ligand of the N and P/Q VSCC do?

A

blocks the release of glutamate

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13
Q

5-HT does?

A

NT that innervates the amygdala and CSTC

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14
Q

What drug classes block the 5-HT reuptake by blocking the 5-HT transporter?

A

SSRI
SNRI

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15
Q

Buspirone use? why?

A

only for GAD, 5-HT1A agonist

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16
Q

SNRI short term vs long term?

A

SHort bad b/c can worsen sx but, long term once beta1 receptors downregulate the fear/worry seem to improve

17
Q

NE regulator of amygdala and which parts of the CSTC?

A

PFC/thalamus

18
Q

SSRI/SNRI 1st line for?

A

GAD, PD, SAD,PTSD, OCD

19
Q

Pregabalin/gabapentin 1st line for?

A

GAD, SAD

20
Q

Prazosin 1st line for?

A

trauma related nightmares in PTSD

21
Q

Propranolol, atenolol use?

A

for performance related SAD

22
Q

Medication considerations (chart)

A
23
Q

GAD more common in male or female?

A

Female 2:1 ratio

24
Q

Onset of GAD?

A

late adolescents or early adulthood

25
Q

Medical conditions potentially that can cause GAD?

A

CV
Neurological
Respiratory

26
Q

Meds that maybe cause GAD?

A

antidepressants
Corticosteroids
Stimulants
Sympathomimetics

27
Q
A

PHAR 358 M1 (2 decks)

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