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pr 3153 > anxiety > Flashcards

anxiety Flashcards

1
Q

generalised anxiety disorder is…

A

excessive anxiety and worries > 6 months

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2
Q

fear circuit regulated by

A

amygdala

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3
Q

worry circuit regulated by

A

cortico striatal thalamic loop

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4
Q

medical conditions associated with anxiety

A

cvs - CHF, MI, IHD
endo - hyperthyroidism, hyperparathyroidism, hypoglycaemia
neuro - dementia, delirium
pulmonary - asthma, COPD

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5
Q

drug induced anxiety

A

sympathomimetics, stimulants, caffeine, levothyroxine, corticosteroids, antidep, dopamine agonists, beta-adrenergic agonist

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6
Q

panic attack definition

A

discrete period of intense fear and discomfort, at least 4 sx and reached a peak within 10 mins.

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7
Q

GAD definition

A

at least 3 symptoms for more days than not for the past 6 months

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8
Q

how long must the obsessions/compulsions last?

A

at least 1hr a day / significantly impairs functioning

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9
Q

what does CBT help in

A

PTSD, PD, OCD

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10
Q

drugs of choice for GAD

A

SSRIs, venlafaxine, pregabalin

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11
Q

drugs of choice for PD, SAD, PTSD

A

SSRIs

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12
Q

OCD drugs

A

SSRIs, clomipramine

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13
Q

when does full response of serotonergic antidep occur

A

generally 3 months

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14
Q

anxiolytics/hypnotics

A

bzd (loraz, alprazolam, clonazepam, diazepam), hydroxyzine, propranolol, pregabalin for GAD (anticonvulsant)

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15
Q

avoid bzd with?

A

opioids –> increased mortalityw

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16
Q

ntm promoting sleep

A

gaba

17
Q

wakefulness promoting ntm

A

ne, da, ach, histamine, orexin

18
Q

preferred benzos for anxiety

A

lorazepam, alprazolam, diazepam, clonazepam

19
Q

insomnia disorder definition

A

at least 3 nights per week, at least 3 months

20
Q

bzd moa

A

potentiates gaba

21
Q

bzd se

A

sedation, drowsiness, amnesia, muscle weakness

22
Q

preferred bzd for elderly

A

lorazepam (shorter half life than diazepam)

23
Q

z hypnotics moa

A

binds to bzd binding sites with gamma and a1 subunits, causing sedation

24
Q

z hypnotics se

A

taste disturbance (zopiclone)

25
Q

antihistamine se

A

anticholinergic effects -> urinary retention, prostatic hypertrophy, angle closure glaucoma

26
Q

antihistamine examples

A

hydroxyzine, promethazine

27
Q

lemborexant moa

A

ox1 and ox2 orexin receptor antagonist

28
Q

lemborexant se

A

somnolence, nightmare

29
Q

lemborexant contraindicated in

A

NARCOLEPSY, severe hepatic impairment, strong cyp3a inhibition/induction

30
Q

trazodone moa

A

inhibit 5ht2a, h1, alpha 1 receptors

31
Q

trazodone se

A

sedation, orthostatic hypot, priapism??

32
Q

precautions for bzd/z-hypnotics

A

respiratory depression
myasthenia gravis
acute narrow angle glaucoma
acute pulmonary insufficiency

pr 3153 (8 decks)

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