Antivirals

Question 1

Which drugs are nucleoSide reverse transcriptase inhibitors?

Answer 1

Abacavir

Lamivudane/ Emtricitibine

Question 2

Which drug is a non-nucleoside reverse transcriptase inhibitor?

Answer 2

Efavirenz

Question 3

Which drug is a nucleoTide reverse transcriptase inhibitor?

Answer 3

tenofovir

Question 4

Which drugs are HIV protease inhibitors

Answer 4

Ritonovir, Darunovir, Atazavanir

Question 5

Which drugs are fusion, entry, and integration inhibitors?

Answer 5

Enfuvitide, Maraviroc, Dolutegravir

Question 6

How do NRTIs work?

Answer 6

Competitively inhibit reverse transcriptase and incorporate into viral DNA. Activated by cellular phosphorylation to triphosphate.

Question 7

Do you need to take NRTIs with food?

Answer 7

yes

Question 8

Toxicities of NRTIs

Answer 8

lactic acidosis with hepatic steatosis due to inhibition of mitochondrial function

Question 9

Abacavir specific toxicities

Answer 9

MI

Hypersensitivity reactions

Question 10

What do you need to do before ever prescribing abacavir?

Answer 10

Check for HLAB 5701 polymorphism

Question 11

HIV drug of choice for patients with HBV?

Answer 11

Lamivudine/ Emtricitabine

Question 12

what NtRTI is given with Emtricitabine?

Answer 12

Tenofovir

Question 13

what are the two formulations of tenofovir

Answer 13

AF and DF

Question 14

Which form of tenofovir has fewer toxicities

Answer 14

AF

Question 15

Toxicities of tenofovir

Answer 15

renal failure, tubular necrosis, fanconi syndrome, fatigue, bone loss

Question 16

Best combo for PEP

Answer 16

Raltegravir/dolutegravir and Tonfovir DF/emtricitabine

Question 17

Best combo for PrEP

Answer 17

Tonofovir DF/emtricitabine