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Block 4 > Antivirals > Flashcards

Antivirals Flashcards

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1
Q

acyclovir indication

A

HSV 1/2; VZV shingles/chickenpox; ocular herpes

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2
Q

valacyclovir indication

A

herpes virus

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3
Q

famiciclovir indication

A

herpes virus

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4
Q

trifluridine indication

A

ocular herpes, HSV1/2

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5
Q

vidarabine indication

A

acute keratoconjunctivitis, recurrent epithelial keratitis HSV 1/2

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6
Q

brivudine indication

A

ocular herpes

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7
Q

ganciclovir indication

A

ocular herpes; CMV infections, lungs, eyes, GI; prophylactic for organ transplants; end-stage HIV-AIDs

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8
Q

valganciclovir indication

A

CMV

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9
Q

cidofovir indication

A

CMV retinitis in AIDs pts only

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10
Q

foscarnet indication

A

CMV retinitis in AIDs pt, acyclovir resistant mucocutaneous HSV

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11
Q

fomivirsen indication

A

CMV retinitis when no response to other drugs

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12
Q

entecavir indication

A

Hep B (more effective)

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13
Q

tenofovir indication

A

Hep B (more effective); HIV

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14
Q

lamivudine indication

A

Hep B (less effective)

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15
Q

adefovir indication

A

Hep B (less effective)

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16
Q

simeprevir indication

A

Hep C

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17
Q

sofosbuvir indication

A

Hep C

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18
Q

ledipasvir indication

A

Hep C

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19
Q

ombitasvir indication

A

Hep C

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20
Q

PEG -IFN indication

A

Hep C

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21
Q

Ribavarin indication

A

Hep C

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22
Q

Amantadine indication

A

influenza A, prophylaxis

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23
Q

rimantadine indication

A

influenza A, prophylaxis

24
Q

Oseltamvir indication

A

influenza A or B, prophylaxis

25
Q

Zanamivir indication

A

influenza A or B, prophylaxis

26
Q

acyclovir MOA

A

prodrug - (VE thymidine kinase) - acyclo- GMP to GTP 1, inhibits vDNA pol 2. chain termination via lack of 3’ OH group

27
Q

valacyclovir MOA

A

prodrug of acyclovir, ester cleaved

28
Q

famiciclovir MOA

A

prodrug of penciclovir ( penciclovir is topical only)

29
Q

trifluridine MOA

A

inhibits vDNA synthesis

30
Q

vidarabine MOA

A

inhibits vDNA synthesis

31
Q

ganciclovir MOA

A

GCV - (VE deoxyguanosine kinase) - mono -di- tri 1. inhibit vDNA pol 2. chain termination

32
Q

valganciclovir MOA

A

prodrug of ganciclovir

33
Q

cidofovir MOA

A

cidofir diphosphate inside cells - inhibits vDNA polymerase

34
Q

fomivirsen MOA

A

antisense drug, forms double helix with mRNA of CMV to block transmission

35
Q

entecavir MOA

A

synthetic nucleoside analogue, prodrug - tri - 1. inhibits HBV RT 2. chain termination

36
Q

tenofovir MOA

A

nucleotide analog RT inhibitor, chain terminator via HBV RT

37
Q

lamivudine MOA

A

synthetic nucleoside analogue, prodrug - tri - chain termination via HBV RT

38
Q

simeprevir MOA

A

HCV protease inhibitor

39
Q

sofosbuvir MOA

A

HCV polymerase inhibitor

40
Q

ledipasvir MOA

A

NS5A inhibitor

41
Q

ombitasvir MOA

A

NS5A inhibitor

42
Q

Amantadine and rimantadine MOA

A

inhibit viral M2 proton channels, no uncoating, no replication

43
Q

oseltamivir and zanamivir MOA

A

neuraminidase inhibitor, analog of sialic acid, prevent release of viral progeny from host

44
Q

acyclovir ADRs

A

topical - burning; oral - N/D/HA/vertigo; IV - renal damage

45
Q

acyclovir contraindications

A

coadmin with other nephrotoxic drugs

46
Q

trifluridine ADRs

A

burning, stinging, edema of eyelid

47
Q

vidarabine ADRs

A

burning, stinging

48
Q

ganciclovir ADRs

A

granulocytopenia (correct with G-CSFs) and thrombocytopenia via inhibition of human DNA polymerase

49
Q

gancicolvir contraindications

A

pregnancy; coadmin with zidovudine

50
Q

foscarnet ADRs

A

nephrotoxic

51
Q

fomivirsen ADRs

A

ocular inflammation (corrected with glucocorticoids)

52
Q

tenofovir ADRs

A

weak inhibition of mammalian DNA polymerase

53
Q

PEG-IFN ADRs

A

flu like sx, depression

54
Q

Ribivarin ADRs

A

hemolytic anemia

55
Q

Ribivarin contraindication

A

pregnancy

56
Q

Amantadine and Rimantadine ADRs

A

usually well tolerated, CNS effects, dizzy, nervousness

57
Q

zanamivir contraindications

A

asthma, COPD

Block 4 (1 decks)

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