Antivirals

Question 1

name a protease inhibitor and state its side effects

Answer 1

nitonavir
atazanavir
(end in navir)
matebolicabnormalities
increased bleeding risk in haemophiliacs

Question 2

name some NRTs and state their side effects

Answer 2

AZT
lamivudine - cytosine analogue
zidovudine - thymine analogue
abacavir, tonofovir (purine analogues)
side effects = lactic acidosis
hepatic steatosis
body fat redistribution

Question 3

which antivirals are effective against hep b

Answer 3

lamivudine
tonofivir
interferons

Question 4

name some NNRTis and state their side effects

Answer 4

efavirenz
nevirapine
rash

Question 5

name an integrase inhibitor and state its side effects

Answer 5

raletgravir

fatigue rash nausea diarrhoea flatulence

Question 6

what is HAART and what are the problems

Answer 6

problem = toxicity
highly active antiretroviral therapy
2 NRTIs + NNRTI
2NRTIs + boosted PI

Question 7

which antivirals are used to treat hep C

Answer 7

interferons

ribavarin

Question 8

which antivirals can be used to treat influenza

Answer 8

oseltamivir
zanamivir
(neuraminidase inhibitors)

Question 9

name a chemokine inibitor

Answer 9

maraviroc –>CCR5

-ve = hepatitis fatigue nausea diarrhoea

Question 10

name a fusion inhibitors

Answer 10

enfurviritide
IM injection
neutropenias and injection site reaction

Question 11

what can ribavirin be used to treat

Answer 11

hep C and RSV

Question 12

what can interferons be used to treat

Answer 12

hep c and hep B