Antivirals Flashcards
what is the combo of tenofovir and emtricitabine used for
pre exposure prophylaxis
post exposure prophylaxis
what are some adverse effect of emtricibabine
hyperpigmentation of the palms and skin discoloration
what are the adverse effects with Zidovudine
bone marrow supression
what are special consideration for lamivudine
Epirvir HBV
resistance is quite common
What is truvada
emtricitabine and tenofovir
1 tab PO dialy
what is atripla
emtricitabine, tenofovir, efavirenz
1 tab PO daily
What is stribild
emtracitabine, tenofivir, elvitegravir, cobivistat
1 tab PO dialy
What is dosing like for efaviranz
600mg PO at bed time
How should you take efaviranz
empty stomach
what are the averse effects with Efaviranz
CNS effects stops after 2-4 wks rash increased LFT Teratogen false positive weed test
what is rilpivirine not used for and what should you avoid using it with?
high viral loads
Proton pump inhibitors
what are some adverse effects with Nevirapine
hepatits and fetal hepatic necrosis
What are the special considerations with Atazanavir and what are the adverse effects
avoid with proton pump inhibtors
indirect hyperbiliruninemia
lack of effects on lipids
what is a special precautions with Darunavir
caution with sulfa allergy
Rash
what are the adverse effects with Raltegravir& Stribild
increased creatine kinase
when do antivirals need to be administered for HSV and VZV
Acyclovir
48-72hr with onset of rash
what is the blackbox warning with Ganciclovir
what are the special considerations
treats CMV bone marrow tox Hydrate aggressively monitor renal function avoid skin contact alkaline and teratogenic
what is the the drug of choice for Tx and Px of CMV
Valganciclovir
what are the special considerations with Valganciclovir
PO only
look alike sound alike with Valcyclovir and Valganciclovir
what is the adverse effect with Foscarnet what does it treat
treat CMV
highly nephrotoxic
what agents are used to treat Hep B virus infection
Adefovir, Lamivudine, entecavir, telbivudine, tenofovir
interferon alfa
What are the adverse effects with Entecavir
dizziness and fatigue
what are the adverse effects of interferon for HVC infection
flu-like syndrome
H/A, myalgia, arthralgias, fatigue, malaise, fever, chills,
improves as treatment continues
what are the special considerations with interferons for HVC
contraindication to therapy hepatic deompensation autoimmune disease history of arrhythmia pregnancy
what are the adverse effects with ribavirin
used for HCV
hemolytic anemia
teratogenic
can’t handle cansules if prego.
what are the special consideration with sofosbuvir
Used for HVC
$1,000 per tab
pan genotypic activity
make it possible to treat some pts with out interferon
how is simeprivir taken
what are special consideration of simeprevir
used for HCV
with food
assessment of Q80K mutation
drug interactions
what is the best method of routine prevention
inactivated influenza vaccine
what are the adverse effects with amantadine
CNS tox increase with elderly
what amantadine use to treat now
no longer used to treat influenza prophylaxis
used to treat parkinsons disease and drug induced EPS
Rimantadine adverse effects
less CNS adverse effects
what can actually happen to disinfectant and antispectic
they may become contaminated with spore or bacteria and transmit infection
