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Pharm Final antibiotics/fungals > Antivirals > Flashcards

Antivirals Flashcards

1
Q

what is the combo of tenofovir and emtricitabine used for

A

pre exposure prophylaxis

post exposure prophylaxis

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2
Q

what are some adverse effect of emtricibabine

A

hyperpigmentation of the palms and skin discoloration

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3
Q

what are the adverse effects with Zidovudine

A

bone marrow supression

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4
Q

what are special consideration for lamivudine

A

Epirvir HBV

resistance is quite common

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5
Q

What is truvada

A

emtricitabine and tenofovir

1 tab PO dialy

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6
Q

what is atripla

A

emtricitabine, tenofovir, efavirenz

1 tab PO daily

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7
Q

What is stribild

A

emtracitabine, tenofivir, elvitegravir, cobivistat

1 tab PO dialy

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8
Q

What is dosing like for efaviranz

A

600mg PO at bed time

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9
Q

How should you take efaviranz

A

empty stomach

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10
Q

what are the averse effects with Efaviranz

A 
CNS effects
stops after 2-4 wks
rash
increased LFT
Teratogen
false positive weed test
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11
Q

what is rilpivirine not used for and what should you avoid using it with?

A

high viral loads

Proton pump inhibitors

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12
Q

what are some adverse effects with Nevirapine

A

hepatits and fetal hepatic necrosis

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13
Q

What are the special considerations with Atazanavir and what are the adverse effects

A

avoid with proton pump inhibtors

indirect hyperbiliruninemia
lack of effects on lipids

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14
Q

what is a special precautions with Darunavir

A

caution with sulfa allergy

Rash

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15
Q

what are the adverse effects with Raltegravir& Stribild

A

increased creatine kinase

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16
Q

when do antivirals need to be administered for HSV and VZV

A

Acyclovir

48-72hr with onset of rash

17
Q

what is the blackbox warning with Ganciclovir

what are the special considerations

A 
treats CMV
bone marrow tox
Hydrate aggressively
monitor renal function
avoid skin contact alkaline and teratogenic
18
Q

what is the the drug of choice for Tx and Px of CMV

A

Valganciclovir

19
Q

what are the special considerations with Valganciclovir

A

PO only

look alike sound alike with Valcyclovir and Valganciclovir

20
Q

what is the adverse effect with Foscarnet what does it treat

A

treat CMV

highly nephrotoxic

21
Q

what agents are used to treat Hep B virus infection

A

Adefovir, Lamivudine, entecavir, telbivudine, tenofovir

interferon alfa

22
Q

What are the adverse effects with Entecavir

A

dizziness and fatigue

23
Q

what are the adverse effects of interferon for HVC infection

A

flu-like syndrome
H/A, myalgia, arthralgias, fatigue, malaise, fever, chills,
improves as treatment continues

24
Q

what are the special considerations with interferons for HVC

A 
contraindication to therapy
hepatic deompensation
autoimmune disease
history of arrhythmia
pregnancy
25
Q

what are the adverse effects with ribavirin

A

used for HCV
hemolytic anemia
teratogenic
can’t handle cansules if prego.

26
Q

what are the special consideration with sofosbuvir

A

Used for HVC
$1,000 per tab
pan genotypic activity
make it possible to treat some pts with out interferon

27
Q

how is simeprivir taken

what are special consideration of simeprevir

A

used for HCV
with food
assessment of Q80K mutation
drug interactions

28
Q

what is the best method of routine prevention

A

inactivated influenza vaccine

29
Q

what are the adverse effects with amantadine

A

CNS tox increase with elderly

30
Q

what amantadine use to treat now

A

no longer used to treat influenza prophylaxis

used to treat parkinsons disease and drug induced EPS

31
Q

Rimantadine adverse effects

A

less CNS adverse effects

32
Q

what can actually happen to disinfectant and antispectic

A

they may become contaminated with spore or bacteria and transmit infection

Pharm Final antibiotics/fungals (3 decks)

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