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DD unit 3 > antivirals > Flashcards

antivirals Flashcards

1
Q

oseltamivir

A

neuraminidase inhibitor (stops budding, translocation)
PO, renal
influenza A and B
nausea

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2
Q

zanamivir

A

neuraminidase inhibitor (stops budding, translocation)
inhale, renal
influenza A and B
bronchospasm in pts with asthma and COPD

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3
Q

amitidine

A

M2 channel blocker
PO, accumulates in lung, breast milk, Renal
influenza A
CNS disturbances

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4
Q

rimantidine

A

M2 channel blocker
PO, accumulates in lung, breast milk. Hepatic
influenza A
CNS, teratogenic

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5
Q

acyclovir

A

DNA pol inhibitor nucleoside analog. selective kinase activity
TOP, IV, renal, lower neonatal clearance
HSV, VZV
encephalopathy with IV

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6
Q

valacyclovir

A

DNA pol inhibitor nucleoside analog
PO, IV, renal
HSV, VZV,

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7
Q

penciclovir

A

DNA pol inhibitor nucleoside analog
TOP, renal
HSV VZV

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8
Q

famiciclovir

A

DNA pol inhibitor nucleoside analog
PO, renal
HSV, VZV

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9
Q

cidofovir

A

DNA pol inhibitor nucleoside analog

use for CMV

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10
Q

foscarnet

A

DNA pol inhibitor (doesn’t need activation)
IV, renal
CMV, and resistant HSV/VZV
nephrotoxic, hypocalcemia,

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11
Q

docosanol

A

prevent viral envelope mbrn fusion
TOP,
HSV
well tolerated

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12
Q

Gancyclovir

A

slows and stops viral DNA pol inhibitor
IV or intraocular, renal
CMV, HBV, opthalmic gel for HSV keratitis
less selective toxicity

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13
Q

valgancyclovir

A

slows and stops viral DNA pol inhibitor
IV or intraocular, renal
CMV, HBV, opthalmic gel for HSV keratitis
myelosuppression, neutropenia

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14
Q

influenza A

A

oseltamivir, zanamivir (resistant to amantadine and rimantadine

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15
Q

influenza B

A

oseltamivir, zanamivir

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16
Q

herpes labialis/genitalis

A

acyclovir, valacyclovir for systemic. Acyclovir and doconasol for topical

17
Q

varicella zoster

A

acyclovir, valacyclovir

18
Q

cytomegalovirus

A

ganciclovir, valganciclovir, cidofovir, foscarnet

DD unit 3 (3 decks)

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