Antivirals

Question 0

Oseltamivir
PK
AE
R

Answer 0

PD- prodrug

AE- GI (nausia)

R- enzyme mutations

Question 1

Neuraminiase inhibitors and their action?

Answer 1

Oseltamivir
Zanamivir

PD: inhibit virus release by inhibiting the enzyme
Admin prior - preventive
Admin (48) - decrease disease

Question 2

Zanamivir
PK
AE
CI

Answer 2

PK- intranasal
AE- airway irritation
CI- COPD, Asthma pts

Question 3

Viral uncoating inhibitors?

Answer 3

Amantadine

Ramantadine

Question 4

Amantadine
PK
AE
CI
R
Use

Answer 4

PK: oral, cross BBB
AE: CNS (insomnia, hallucinations, seizures)
CI: pregnancy, nursing, psychosis
R: 50% cross resistance
Use: Influenza A

Question 5

Rimantadine

Answer 5

PK: no BBB
AE: less severe
CI: pregnancy, nursing, monitor psychosis
R: 50% cross resistance
Use: influenza A

Question 6

Purine and pyrimidine analogs?

Answer 6

Ribavirin

Question 7

Ribavirin
PD
AE
CI
USE

Answer 7

PD:triphosphate, inhibit GTP formation, inhibit mRNA capping, inhibit RNA dependent RNA polymerase
AE; dose dependent anemia (binds to RBC)
CI: pregnancy
USE: RNA< DNA viruses (RSV, CMV, Lassa fever)

Question 8

What groups can you use in Hepatitis treatment?

Answer 8

Interferons (a, B, y)
Nucleotide analogs (lamivudine, Telbivudine, Adefovir, Entecavir)

Question 9

Interferons a, B
PK
PD
AE
Int
Use

Answer 9

PD; normally in cells, immune response inhibit RNA, DNA synthesis
PK: intralesion, pegylated: add polyethyl tail decrease PK
AE:
1. flu like (fever, myalgia, chills)
2. fatigue
USE:
a: HCV, HBV, condyloma acuminata, hairycell leukemia, kaposi carcoma
B: multipe sclerosis

Question 10

INT-y
PK
USE

Answer 10

PK: in T cells (immune cells)
Use: granulomatous diseases (chronic inherited)