Antivirals

Question 1

List the influenza antivirals

Answer 1

amantadine, rimantadine, zanamivir, oseltamivir

Question 2

Influenza antiviral mechanism of action

Answer 2

not fully understood, but inhibits viral replication in some way

Question 3

Amantadine and rimantadine therapeutic uses

Answer 3

prophylaxis of Influenza A, treatment of Influenza A

Question 4

Zanamivir and oseltamivir therapeutic uses

Answer 4

prophylaxis of Influenza A & B, treatment of Influenza A & B

Question 5

List the herpes antivirals

Answer 5

acyclovir, valacyclovir, famciclovir, penciclovir

Question 6

Herpes antiviral mechanism of action

Answer 6

inhibit herpes viral replication by inhibiting viral DNA polymerase

Question 7

Therapeutic uses for herpes antivirals

Answer 7

Genital herpes, varicella-zoster virus, cold sores (mostly HSV-1)

Question 8

Which herpes antivirals are used to treat genital herpes?

Answer 8

acyclovir, valacyclovir, famciclovir (all po)

Question 9

Genital herpes is caused by what virus?

Answer 9

Herpes simplex virus types 1 & 2

Question 10

Chickenpox is caused by what virus?

Answer 10

Varicella zoster virus

Question 11

Shingles is caused by what virus?

Answer 11

Latent varicella zoster virus

Question 12

List the categories of HIV antivirals

Answer 12

Nucleoside Reverse Transcriptase Inhibitors, Nonnucleoside Reverse Transcriptase Inhibitors, Protease Inhibitors

Question 13

What HIV antiviral is used in perinatal transmission prophylaxis?

Answer 13

Zidovudine

Question 14

What is the basic HIV antiviral regimen for post-exposure prophylaxis?

Answer 14

2 reverse transcriptase inhibitors

Ex: zidovudine + lamivudine or zidovudine + emtrictabine, tenofovir + lamivudine or tenofovir + emtricitabine