Antiviral drugs Flashcards
1
Q
Give examples of the mechanisms of action of antiviral drugs
A
- Ion channel blockers
- Reverse transcriptase inhibitors
- DNA polymerase inhibitors
- Neuraminidase inhibitors
2
Q
What is the drug action against influenza A, retroviruses, herpes simplex and influenza A and B?
A
- Influenza A - ion channel blocker
- Retrovirus - reverse transcriptase inhibitor
- Herpes simplex - DNA polymerase inhibitor
- Influenza A and B - neuraminidase inhibitor
3
Q
What are the properties of aciclovir?
A
- Inhibits viral DNA polymerase
- High specificity for herpes simplex
- Oral, IV, topical
- Minimal side effects
- Uses FIV, viral eye infection
4
Q
What are the properties of amantadine and rimantadine?
A
- Blocks viral M2 ion channel (stops uncoating and replication)
- Uses influenza A
- Oral
- Minimal side effects
5
Q
What are the properties of zidovudine?
A
- Nucleoside reverse transcriptase inhibitor
- Retroviruses
- Oral, IV
- Short term, minor reversible side effects
- Long term anaemia, GIT disturbances
- Uses FLV and FIV
6
Q
What are the properties of zanamivir and oseltamivir?
A
- Treatment and prophylaxis of influenza A and B
- Neuraminidase inhibitor
- Active against canine parvo, feline panleukopenia, kennel cough, canine flu
