Antiviral drugs Flashcards
1
Q
(Non-) Nucleoside reverse transcriptase inhibitors
A
MOA: inhibit reverse transcriptase, compete with substrate - NUCLEIC ACID SYNTHESIS
AE: bone density, neurotoxicity, hepatotoxicity, hypersensitivity, cardiotoxicity (NNRTI), GIT upset (NRTI)
2
Q
Protease inhibitor
A
MOA: interfere with PROTEIN SYNTHESIS
AE: bleeding, bone density, cardiotoxicity, GIT
3
Q
Entry inhibitor
A
MOA: prevent viral entry
AE: hypersensitivity, hepatotoxicity, GIT
4
Q
Integrase inhibitor (INSTI)
A
MOA: inhibit integrase (inserts viral genetic information into host genome)
AE: neurotoxicity, hypersensitivity, GIT
5
Q
anti-HSV targets
A
- Entry
- Nucleic acid synthesis
6
Q
anti-HCV targets
A
- Protein synthesis + processing
- Replication
7
Q
anti-Influenza targets
A
- Viral uncoating (Amantadine for Influenza A)
- Viral release (Neuraminidase inhibitor for Influenza)
8
Q
Antiviral targets
A
viral replication (polymerase inhibitors)
9
Q
Oseltamivir
A
- Neuraminidase inhibitor
- Influenza
- AE: GIT, malaise
10
Q
Aciclovir, valaciclovir
A
- Inhibits DNA polymerase
- HSV, VSV
- AE: GIT, malaise
11
Q
Ritonavir
A
- Protease inhibitor
- Used in ART, slows metabolism of other drugs
- AE: cardiotoxicity, hepatotoxicity, GIT
