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Antiviral Drugs > Antiviral Drugs > Flashcards

Antiviral Drugs Flashcards

1
Q

Mention 4 DNA viruses

A

Human papilloma
Chicken pox
Herpes virus
Adenoviruses

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2
Q

Mention 4 RNA viruses

A

Influenza
Measles
Mumps
Hepadnaviruses

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3
Q

Retro viruses such as hiv have what?

A

-reverse transcriptase
-integrase
-glycoproteins gp41, gp120

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4
Q

Name the 5 group of herpes viruses and locations

A

-herpes simplex 1: oral mucosa
-herpes simplex 2: genital herpes
-varicella zoster; face and limbs (chicken pox)
-cytomegalovirus;esophagitis,CNS (encephalitis) retina
-Epstein Barr virus; infectious mononucleosis (lymphatic and immune system

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5
Q

List 5 drugs for herpes viruses

A

-Aciclovir
-famciclovir
-valaciclovir
-ganciclovir
-foscarnet

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6
Q

Mechanism of action for antiviral drugs for herpes

A

-Antiviral drugs bind with Timindine kinase of herpes and phosphotransferase of CMV to form mono phosphate of antiviral drugs ,then enzymes of host cells bind also to form Diphosphate, triphosphate which leads to competition between antiviral drugs and triphosphate and guanine triphosphate leading to appearance of DNA fragments leading to inhibition of viral replication and inhibition of viral DNA polymerase

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7
Q

Pharmacokinetics of Aciclovir what is it’s bioavailability where it penetrates

A

-Bioavailability 10-20%
-Accumulate in herpes vesicles and penetrate blood brain barrier and placenta

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8
Q

Routes of application Aciclovir

A

Orally
Local
Intravenous

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9
Q

Penciclovir can be applied?

A

Locally on the lip

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10
Q

Drugs for cytomegalovirus and indications

A

Ganciclovir
Valganciclovir
Indications: retinitis and prevention of cytomegalovirus infections with patients with compromised immune system and after organ transplantation

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11
Q

Antiviral Drugs for influenza (mechanism of action)

A

-They inhibit M2 protein and inhibit virus from entering cells and violate protein assembling
-They also they violate synthesis of hemagglutinin

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12
Q

Influenza viral drugs that inhibit m2 protein and prevent viral assembly

A

-Amantadine
-Rimantadine

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13
Q

Influenza virus drugs that inhibit neuraminidase and can prevent viral escape from infected cell and penetration of cells

A

-oseltamivir
-zanamivir

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14
Q

Unwanted side effects of influenza drugs

A

-Insomia ,hallucinations and slurred speech
-Headache
-Git disturbance

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15
Q

What are the dose and route of administration of oseltamivir

A

Oral 75mg oseltamivir

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16
Q

Hiv drugs Give 2 drugs that inhibits Reverse transcriptase enzymes Nucleoside and non nucleoside

A

-Abacavir
-didanosin(nucleoside)
Nonnucleoside: nevirapin

17
Q

Hiv integrase inhibitor

A

Ratelgravir

18
Q

Hiv protease inhibitors

A

Saquinavir
Ritonavir

19
Q

Hiv inhibitors of fusion

A

Enfuviktide

Antiviral Drugs (1 decks)

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