Antiviral Drugs

Question 1

Drugs for Herpes Virus

Answer 1

Acyclovir, Valacyclovir, Penciclovir, Famciclovir

Question 2

Drugs for CMV

Answer 2

Ganciclovir and Valganciclovir

Question 3

Drugs Active against HSV and/or CMV

Answer 3

Cidofovir and Foscarnet

Question 4

ART: Entry (CCR5) Inhibitors

Answer 4

Maraviroc (Selzentry)

Question 5

ART: Fusion Inhibitors

Answer 5

Enfuvirtide (T-20, Fuzeon)

Question 6

ART: Nucleoside RT Inhibitors (NRTIs)

Answer 6

Zidovudine, Abacavir, Stavudine, Didanosine

Question 7

ART: Nucleotide RT Inhibitors

Answer 7

Tenofovir

Question 8

Retrovir

Answer 8

Zidovudine (aka, AZT, azidothymidine, ZDV - GSK, 1987

Question 9

Videx

Answer 9

didanosine, ddI, dideoxyinosine - BMS, 1991

Question 10

Zerit

Answer 10

stavudine, d4T - BMS, 1994

Question 11

Epivir

Answer 11

lamivudine, 3TC - GSK, 1995

Question 12

Combivir

Answer 12

lamivudine and zidovudine - GSK, 1995

Question 13

Ziagen

Answer 13

abacavir - GSK, 1997

Question 14

Videx EC

Answer 14

enteric coated didanosine - BMS, 2000

Question 15

Trizivir

Answer 15

abacavir, zidovudine, lamivudine - GSK, 2000

Question 16

Viread

Answer 16

tenofovir disoproxil fumarate, Gilead, 2001

Question 17

Emtriva

Answer 17

FTC, emtricitabine - Gilead Sciences, 2003

Question 18

Truvada

Answer 18

tenofovir disoproxil/emtricitabine - Gilead Sciences, Inc. 2004

Question 19

Epzicom

Answer 19

abacavir/lamivudine - GSK, 2004

Question 20

Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs)

Answer 20

Brand Names: Viramune, Rescriptor, Sustiva, Atripla, Intelence, Edurant, Complera

Question 21

NNRTI: Viramune

Answer 21

nevirapine, BI-RG-587, 1996

Question 22

NNRTI: Rescriptor

Answer 22

delaviridine, DLV, 1997

Question 23

NNRTI: Sustiva

Answer 23

efavirenz, 1998

Question 24

NNRTI: Atripla

Answer 24

efavirenz, emtricitabine, tenofovir, 2006

Question 25

NNRTI: Intelence

Answer 25

etravirine, 2008

Question 26

NNRTI: Edurant

Answer 26

rilpivirine, 2011

Question 27

NNRTI: Complera

Answer 27

rilpivirine, emtricitabine, tenofovir, 2011

Question 28

Integrase Inhibitors

Answer 28

Raltegravir (Isentress), Elvitegravir

Question 29

Isentress

Answer 29

raltegravir, Marck 2008, integrase inhibitor

Question 30

Stribild

Answer 30

elvitegravir, cobicistat, tenofovir, emtricitabine, Gilead 2012, integrase inhibitor

Question 31

dolutegravir

Answer 31

integrase inhibitor, Gilead - sumbitted to FDA in 2013

Question 32

Protease Inhibitors

Answer 32

Invirase, Crixivan, Norvir, Viracept, Fortovase, Agenerase, Kaletra, Lexiva, Reyataz, Aptivus, Prezista

Question 33

Invirase

Answer 33

PI, saquinavir mesylate, SQV 1995

Question 34

Crixivan

Answer 34

PI, indinavir 1996

Question 35

Norvir

Answer 35

PI, ritonavir, ABT-538 1996

Question 36

Viracept

Answer 36

PI, nelfinavir mesylate, NFV 1997

Question 37

Fortovase

Answer 37

PI, saquinavir 1997

Question 38

Agenerase

Answer 38

PI, amprenavir 1999

Question 39

Kaletra

Answer 39

PI, lopinavir and ritonavir 2000

Question 40

Lexiva

Answer 40

PI, fosamprenavir calcium 2003

Question 41

Reyataz

Answer 41

PI, atazanavir sulfate 2003

Question 42

Aptivus

Answer 42

PI, tipranavir 2005

Question 43

Prezista

Answer 43

PI, darunavir 2006

Question 44

Drugs to suppress viral replication of HepB

Answer 44

NNRTIs: Lamivudine (Epivir), Adefovir (Hepsera), Entecavir (Baraclude), Telbivudine (Tyzeka), Tenofovir (Viread)D

Question 45

Drugs that modulate immune response

Answer 45

Interferons; classes: alpha-2b –> for treatments of acute and chronic hepatitis C/ alpha-2a —> for treatment of chronic HepC

Question 46

Drugs to suppress viral replication of HepC

Answer 46

Telaprevir/Boceprevir, Ribavirin

Question 47

Anti-influenza agents

Answer 47

Amantadine, Rimantadine, Zanamivir (Relenza), Oseltamivir (Tamiflu)