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32 Thyroid drugs > Antithyroid agents > Flashcards

Antithyroid agents Flashcards

1
Q

Antithyroid agents (3 groups)

A

Thioamide drugs
Betablockers
Iodine salts

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2
Q

Thioamide drugs (2 drugs)

A

Methimazole

Propylthiouracil (PTU)

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3
Q

Thioamide drugs - MOA

A

Inh synthesis of thyroid hormones by inh thyroperoxidase-catalysed steps

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4
Q

How does propylthiouracil differ from methimazole?

A

PTU also inhibits T4 to T3 conversion in peripheral tissues

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5
Q

Thioamide drugs - indications

A

Graves disease

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6
Q

Drug of choice for pregnant women with graves disease

A

Prophylthiouracil (before and during 1st trimester)

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7
Q

Thioamide drugs - adverse effects

A 
Relapse
Maculopapular rash, arthalgia
Lupus-like sundrome
Agranulocytosis
Fatal liver failure
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8
Q

Methimazole - adverse effects

A

Birth defects (cross placenta & breast milk)

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9
Q

Betablockers as antithyroid drug (1 drug)

A

Propanolol

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10
Q

Betablockers - MOA as antithyroid drug

A

Inhibits conversion of T4 to T3

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11
Q

Betablockers - indications as antithyroid drugs

A

Severe thyrotoxicosis

Drug used before surgery or RAI treatment

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12
Q

Propanolol - why is it used in hyperthyroidism?

A

Reduces cardiovascular symptoms

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13
Q

Iodine salts (2 drugs)

A

Potassium iodine

Sodium iodine

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14
Q

Iodine salts - MOA

A

Inhibit release of thyroid hormones

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15
Q

Drug used in case of nuclear reactor accidents

A

Potassium iodine

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16
Q

Potassium iodine - indications

A

Decrease size of thyroid - surgery, RAI treatment
Acute thyrotoxicosis
Nuclear accident

17
Q

Sodium iodine - indications

A

RAI-treatment

18
Q

Sodium iodine - MOA

A

Concentrates in the thyroid gland and destroys tissue through radiation

19
Q

Sodium iodine - contraindications

A

Pregnancy: destroys fetal thyroid tissue

20
Q

RAI-treatment - interactions

A

Thioamide drugs: less efficient treatment, more recurrences.

21
Q

Potassium iodine - adverse effects

A

Salivary gland swelling
Metallic tase
Sore gums

32 Thyroid drugs (2 decks)

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