Antithrombotics Flashcards
Aspirin MOA
COX inhibitor, inhibits thromboxane synthesis
Aspirin indication
primary/secondary prevention
and acute coronary syndromes, PCI, recurrent stroke
ADP Receptor Blocker MOA
prevent platelet aggregation; these are PRODRUGS
ADP examples
irreversible=grel: clopidogrel, prasugrel
Reversible: Ticagrelor +aspirin
ADP Use
Irreversibles:
Clopidigril :w aspirin during/after PCI or alone if aspirin isn’t tolerated
Prasugrel: PCI related thrombosis
Reversible: Ticagrelor w Aspirin for thombotic events with ACS or MI/ST elevation
G2b3a inhibitors MOA
Bind GP IIb/IIIa – prevent fibrinogen binding and subsequent crosslinking of platelets
G2b3a inhibitors examples
A: abciximab (irreversible)
T: tirofiban
E: eptifibatide
G2b3a inhibitors indication
efficacious antiplatelets
G2b3a inhibitors warnings
Thrombocytopenia
Heparin MOA
heparin/enoxaparin
enhances antithrombin 3
Heparin adverse effects
bleeding
HIT
Thombocytopenia
Heparin indication
• Prophylaxis: DVTs and PE
• Thromboembolic events. related to unstable angina, MI, AF
• Acute DVT & PE
Acute Coronary Syndrome (+ antiplatelet)
F10a inhibitors examples
rivaroxABAN (xarelto)
apixABAN
F10a indication
-ABAN
Prophylaxis: DVT, PE
Stroke prevention with non-valvular A-fib
F10a MOA
-ABAN
Inhibits free & clot-bound Xa
**no antidote to bleeding