Antithrombotic, Fibrinolytic, and Coagulant Substances Released from or Found on the Surface of Intact Endothelial Cells

Question 1

Inhibits platelet adhesion and aggregation; stimulates vasodilation

Answer 1

Prostacyclin (Prostaglandin I2 or PGI2)

Question 2

Stimulates vasodilation

Answer 2

Adenosine (Metabolic product of ATP and ADP)

Question 3

Destroys ADP, limits platelet activation

Answer 3

ADPase

Question 4

Endothelial cell receptor for thrombin

Answer 4

Thrombomodulin

Question 5

Binds and inactivates thrombin and enhances anticoagulant and fibrinolytic action of protein C found in the plasma

Answer 5

Thrombomodulin

Question 6

Coats the endothelial cell surface and weakly enhances the activity of antithrombin III, a plasma anticoagulant

Answer 6

Heparan Sulfate

Question 7

Converts plasminogen to plasmin, which plays an important role in fibrinolysis. It is released only on appropriate stimulus, such as vessel injury, to prevent excessive clot formation at the site of injury and begin slow clot dissolution as the injured blood vessel heals.

Answer 7

Tissue Plasminogen Activator (TPA)

Question 8

Regulatory protein for fibrinolytic

Answer 8

Plasminogen Activator Inhibitor-1

Question 9

Protein produced in endothelium and stored in sub-endothelium (in the form of Weibel- Palade bodies) before secretion into the plasma and attachment to factor VIII: C)

Answer 9

Von Willebrand Factor (vWF)